{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:51:08Z","timestamp":1791341468490,"version":"4.3.1"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review aimed to investigate the role of the C\u2010X3\u2010C motif ligand 1\/chemokine receptor 1 C\u2010X3\u2010C motif (CX3CL1\/CX3CR1) axis in the pathogenesis of periodontitis. Furthermore, as a secondary objective, we determine whether the CX3CL1\/CX3CR1 axis could be considered complementary to clinical parameters to distinguish between periodontitis and rheumatoid arthritis (RA) and\/or systemically healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protocol used for this review was registered in OSF (10.17605\/OSF.IO\/KU8FJ). This study was designed following\u00a0Preferred Reporting Items for Systematic Review and Meta\u2010Analysis guidelines. Records were identified using different search engines (PubMed\/MEDLINE, Scopus, Science Direct, and Web of Science) from August 10, 2006, to September 15, 2023. The observational studies on human subjects diagnosed with periodontitis and RA and\/or systemically healthy were selected to analyze CX3CL1 and CX3CR1 biomarkers. The methodological validity of the selected articles was assessed using NIH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six articles were included. Biological samples (gingival crevicular fluid [GCF], saliva, gingival tissue biopsies, serum) from 379 subjects (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009275 exposure group and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104 control group) were analyzed. Higher CX3CL1 and CX3CR1 chemokine levels were found in subjects with periodontitis and RA compared with periodontal and systemically healthy subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Very few studies highlight the role of the CX3CL1\/CX3CR1 axis in the pathogenesis of periodontitis; however, increased levels of these chemokines are observed in different biological samples (GCF, gingival tissue, saliva, and serum) from subjects with periodontitis and RA compared with their healthy controls. Future studies should focus on long\u2010term follow\u2010up of subjects and monitoring changes in cytokine levels before and after periodontal therapy to deduce an appropriate interval in health and disease conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1181","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:39:52Z","timestamp":1707273592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of the CX3CL1\/CX3CR1 axis as potential inflammatory biomarkers in subjects with periodontitis and rheumatoid arthritis: A systematic review"],"prefix":"10.1002","volume":"12","author":[{"given":"Mario A.","family":"Alarc\u00f3n\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Biomedical Science, Faculty of Chemical\u2010Biological Sciences Autonomous University of Guerrero  Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta S.","family":"Becerra\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Institute of Research of Bioscience, University Center of Los Altos University of Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Guerrero\u2010Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Research Center in Molecular Biology of Chronic Diseases, Southern University Center University of Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6963-8289","authenticated-orcid":false,"given":"Seyed A.","family":"Mosaddad","sequence":"additional","affiliation":[{"name":"Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University  Chennai India"},{"name":"Student Research Committee, School of 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