{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:20:28Z","timestamp":1790803228968,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373179"],"award-info":[{"award-number":["81373179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we investigated the development of the Wnt signaling pathway in vitamin D (VitD) to improve systemic lupus erythematosus in mice to breakthrough clinical treatment approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Body weight changes were recorded during rearing. Antinuclear antibodies (ANA), anti\u2010dsDNA, and anti\u2010snRNP were detected in the mouse serum using an enzyme\u2010linked immunosorbent assay. Apoptosis of Th1 and Th2 immune cells in mice was detected using flow cytometry. Reverse transcription polymerase chain reaction was used to detect the expression of T\u2010bet, GATA3, and Wnt3a mRNA in the spleens of each group. Western blot analysis was performed to detect the expression of Wnt1, p\u2010\u03b2\u2010catenin, \u03b2\u2010catenin, glycogen synthase kinsase3\u03b2 (GSK\u20103\u03b2), Wnt3a, c\u2010myc, and cyclin D1 protein in mice spleens. \u03b2\u2010catenin in mice spleen was visualized using immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>VitD did not substantial reduce the body weight of MRL\/LPR mice, whereas the inhibitor did. VitD notably decreased the concentrations of ANA, anti\u2010double\u2010stranded DNA, and anti\u2010snRNP in the serum of MRL\/LPR mice and alleviated apoptosis of Th1 and Th2 cells. VitD markedly increased the expression of T\u2010bet and GATA mRNA in the spleen of MRL\/LPR mice and consequently increased the levels of Wnt3a and \u03b2\u2010catenin. Western blot analysis revealed that the levels of GSK\u20103\u03b2, p\u2010\u03b2\u2010catenin, Wnt1, Wnt3a, c\u2010myc, and cyclin D1 could be reduced by VitD, compared with MRL\/LPR. Immunohistochemistry demonstrated that the expression of \u03b2\u2010catenin was the most pronounced in the spleen of MRL\/LPR mice, and the expression level of \u03b2\u2010catenin decreased substantially after VitD intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VitD can further inhibit the nuclear translocation of \u03b2\u2010catenin by downregulating the expression of Wnt ligands (Wnt1 and Wnt3a), which reduces the expression of the downstream target gene cyclin D1. Systemic lupus erythematosus in mice was improved by inhibiting the activation of Wnt\/\u03b2\u2010catenin signal pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1192","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T02:04:35Z","timestamp":1709085875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: Vitamin D improves autoimmune diseases by inhibiting Wnt signaling pathway"],"prefix":"10.1002","volume":"12","author":[{"given":"Minshu","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Pediatrics General Hospital of Central Theater Command Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology General Hospital of Central Theater Command Wuhan 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