{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:45:23Z","timestamp":1790819123788,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acute necrotic collection (ANC), acute peripancreatic fluid collection (APFC), pleural effusion, and ascites are common early complications of acute pancreatitis. This study aimed to investigate the relationship between 12 serum cytokines and the early complications and severity of acute pancreatitis (AP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinical data of 307 patients with AP, and divided them into severe group and mild\u2010to\u2010moderate group according to the revised Atlanta classification. Propensity score matching was used to control for confounding factors. Binary logistic regression analysis was used to explore the relationship between cytokine levels and early complications of AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum levels of interleukin (IL)\u20101\u03b2, IL\u20105, IL\u20106, IL\u20108, IL\u201010, IL\u201017, and tumor necrosis factor\u2010\u03b1 were significantly higher in the severe acute pancreatitis (SAP) group than in the non\u2010SAP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). After adjusting for confounding factors, the upper quartiles of IL\u20106, IL\u20108, and IL\u201010 were associated with an increased risk of ANC compared with those in the lowest quartile (IL\u20106: quartile 3, odds ratio [OR]\u2009=\u20093.99, 95% confidence interval [CI]\u2009=\u20091.95\u20138.16; IL\u20108: quartile 4, OR\u2009=\u20092.47, 95% CI\u2009=\u20091.27\u20134.84; IL\u201010: quartile 2, OR\u2009=\u20092.22, 95% CI\u2009=\u20091.09\u20134.56). APFC was associated with high serum levels of IL\u20106 (quartile 3, OR\u2009=\u20091.32, 95% CI\u2009=\u20091.02\u20131.72), pleural effusions were associated with high serum levels of IL\u20101\u03b2, IL\u20106, IL\u20108, and IL\u201010 (IL\u20101\u03b2: quartile 4, OR\u2009=\u20092.36, 95% CI\u2009=\u20091.21\u20134.58; IL\u20106: quartile 3, OR\u2009=\u20094.67, 95% CI\u2009=\u20092.27\u20139.61; IL\u20108: quartile 3, OR\u2009=\u20092.95, 95% CI\u2009=\u20091.51\u20135.79; IL\u201010: quartile 4, OR\u2009=\u20093.20, 95% CI\u2009=\u20091.61\u20136.36), and high serum levels of IL\u20106 and IL\u201010 were associated with an increased risk of ascites (IL\u20106: quartile 3, OR\u2009=\u20093.01, 95% CI\u2009=\u20091.42\u20136.37; IL\u201010: quartile 3, OR\u2009=\u20092.57, 95% CI\u2009=\u20091.23\u20135.37).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum cytokine levels, including IL\u20101\u03b2, IL\u20106, IL\u20108, and IL\u201010 may be associated with the occurrence of early complications of AP. In daily clinical practice, IL\u20106 may be the most worthwhile cytokine to be detected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1203","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T07:15:25Z","timestamp":1709018125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The relationship between inflammatory cytokines and in\u2010hospital complications of acute pancreatitis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-1556","authenticated-orcid":false,"given":"Jiaxin","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xuzhou Medical University  Xuzhou 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