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High mobility group box 1 (HMGB1) is an important proinflammatory cytokine, which has been confirmed to be highly expressed in the peripheral circulation and epidermis tissues of psoriasis patients. The regulatory effect of HMGB1 on IL\u201017A expression and function has been reported in some inflammatory and autoimmune diseases by the\u00a0HMGB1\u2010Toll\u2010like receptor 4 (TLR4)\u2010interleukin (IL)\u201023\u2010IL\u201017A pathway. While, in the pathological environment of psoriasis, whether HMGB1 can exert the regulatory effect on IL\u201017A is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to evaluate the role of HMGB1\u2010TLR4\u2010IL\u201023\u2010IL\u201017A pathway in the pathogenesis of psoriasis and explore the possible regulatory mechanism of HMGB1 on Th17 cell differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum levels of HMGB1, TLR4, IL\u201023, and IL\u201017A were quantified in 50 patients with moderate\u2010to\u2010severe plaque psoriasis and 30 healthy controls. Peripheral blood mononuclear cells \u00a0were acquired from 10 severe psoriasis patients and administrated by different concentrations of recombinant\u2010HMGB1 (rHMGB1) to detect the Th17 cell percentage, mRNA and protein levels of TLR4, IL\u201023, IL\u201017A and retinoid\u2010related orphan receptor \u03b3t (ROR\u03b3t).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The serum levels of HMGB1, TLR4, IL\u201023, and IL\u201017A in psoriasis patients were significantly higher than healthy controls, especially in severe patients, and positively correlated with the severity index. There were also positive correlations between every two detected indicators of HMGB1, TLR4, IL\u201023, and IL\u201017A. In vitro study, rHMGB1 can promote the elevated expression of Th17 cell percentage as well as TLR4, IL\u201023, IL\u201017A, and ROR\u03b3t in a dose\u2010dependent manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HMGB1 can contribute to the pathogenesis of psoriasis by regulating Th17 cell differentiation through HMGB1\u2010TLR4\u2010IL\u201023\u2010ROR\u03b3t pathway, then promotes\u00a0IL\u201017A production and aggravates inflammation process. Targeting HMGB1 may be a possible potential candidate for the immunotherapy of psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1205","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T02:04:31Z","timestamp":1709085871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["HMGB1 regulates Th17 cell differentiation and function in patients with psoriasis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9754-9575","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Dermatology Binzhou Medical University Hospital Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Binzhou Medical University Hospital Binzhou 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