{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:10:11Z","timestamp":1785345011434,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K15606"],"award-info":[{"award-number":["23K15606"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anesthetic agents, particularly intravenous anesthetics, may affect immune function and tumorigenic factors. We herein investigated whether the anti\u2010inflammatory effects of anesthetic agents are attributed to their antioxidant properties. The antioxidant and anti\u2010inflammatory effects of remimazolam, a new anesthetic, remain unclear. We hypothesized that remimazolam exerts anti\u2010inflammatory effects due to its antioxidant properties, which may affect the postoperative inflammatory response. This retrospective clinical study examined this hypothesis using laboratory and clinical approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The antioxidant effects of remimazolam and dexmedetomidine were assessed by electron spin resonance (ESR) spectroscopy, and postoperative inflammatory responses were compared in 143 patients who underwent transcatheter aortic valve replacement at Kindai University Hospital between April 2021 and December 2022. The primary endpoint was the presence or absence of the antioxidant effects of the anesthetics themselves using ESR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Remimazolam at clinical concentrations exerted antioxidant effects, whereas dexmedetomidine did not. Increases in C\u2010reactive protein (CRP) levels on POD3 from preoperative values were significantly smaller in the remimazolam group than in the dexmedetomidine group (1.33\u2009\u00b1\u20091.29 vs. 2.17\u2009\u00b1\u20091.84, <jats:italic>p<\/jats:italic>\u2009=\u2009.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Remimazolam exerted stronger anti\u2010inflammatory effects than dexmedetomidine, and these effects were enhanced by its antioxidant properties, which may have affected postoperative CRP production.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1218","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:58:56Z","timestamp":1710417536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Anti\u2010inflammatory potential of remimazolam: A laboratory and clinical investigation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3460-3630","authenticated-orcid":false,"given":"Shota","family":"Tsukimoto","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology Kanagawa Dental University Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhiro","family":"Kitaura","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kindai University Faculty of Medicine  Osakasayama Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology Kanagawa Dental University Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uno","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology Kanagawa Dental University Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kanagawa Dental University  Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Dental Education Kanagawa Dental University Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinchi","family":"Nakao","sequence":"additional","affiliation":[{"name":"Perioperative Management Center Okanami General Hospital Iga Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kindai University Faculty of Medicine  Osakasayama Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhumi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Kindai University Faculty of Medicine  Osakasayama Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Sanuki","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology Kanagawa Dental University Yokosuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000267503.85085.c0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-020-02788-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.851"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9268454"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.08.89"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0803600113"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu200"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14147-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000662"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2016.69.2.126"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S156792"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002491"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-21-878"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/905238"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.07.027"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.11.050"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108331"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/782137"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5698931"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.13-86"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200211000-00015"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510270072043"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400025200"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-013-8384-0"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8907"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12342"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.544431"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.03.014"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2007.02.008"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sopen.2019.06.001"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4868"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3556-0"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.1218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:20:30Z","timestamp":1711545630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.1218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/iid3.1218"],"URL":"https:\/\/doi.org\/10.1002\/iid3.1218","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1218"}}