{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:19:57Z","timestamp":1784204397683,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Helminths are potent immunomodulators and in their chronic infection state they may protect against allergy\u2010related disease and atopy. However, they are also known for inducing allergic conditions. This study aimed to assess the association between helminths,\u00a0 atopy and allergic conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 461 school children participated in this cross\u2010sectional study. Data on allergic symptoms and a range of confounding variables was gathered from parents via an interviewer\u2010led questionnaire. Skin sensitization to house dust mite and cockroaches was analyzed, and a stool sample was collected for helminth analysis. Serum total Immunoglobulin E using enzyme\u2010linked immunosorbent assay and eosinophil count were also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall sensitivity to both allergens was 2.4%. Self\u2010reported allergic outcomes in the last 12 months for the 461 participants had been : wheezing 3.7%, asthma 2.2%, eczema 13.2% and hay fever 6.9%. Overall, the prevalence of helminth infection was 11.9% (53\/444). A borderline significant association was found between atopy and any allergy symptoms (odds ratio [OR]: 3.32, 95% confidence interval [95% CI: 0.99, 11.1], <jats:italic>p<\/jats:italic>\u2009=\u2009.052). There was no significant association between helminths and atopy (OR: 0.64 [95% CI: 0.29, 1.41], <jats:italic>p<\/jats:italic>\u2009=\u2009.268) and also between helminths and allergic symptoms (OR: 0.64 [95% CI: 0.29, 1.41], <jats:italic>p<\/jats:italic>\u2009=\u2009.268). Bivariate analysis showed keeping an animal in the house increases the risk of atopy while maternal and paternal history of allergy increases the risk of developing allergic symptoms in the children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>This study found a non\u2010significant inverse association between helminths infection and atopy and allergic disorders, likely due to reduced statistical power, resulting in a lower prevalence of atopy and allergic conditions. A high powered longtitudinal study is necessary to explore the casuality and potential therapeutic benefits of helminths for allergic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1222","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T13:14:20Z","timestamp":1711113260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between helminth infection and allergic disorders among children in Batu, Ethiopia"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-4455","authenticated-orcid":false,"given":"Sosina","family":"Walelign","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mheret","family":"Tesfaye","sequence":"additional","affiliation":[{"name":"Bacteriology and Mycology National Reference Laboratory Ethiopian Public Health Institute Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geremew","family":"Tasew","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic, and Zoonotic Diseases Research Directorate Ethiopian Public Health Institute Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassu","family":"Desta","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-4629","authenticated-orcid":false,"given":"Aster","family":"Tsegaye","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bineyam","family":"Taye","sequence":"additional","affiliation":[{"name":"Department of Biology Colgate University Hamilton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02512.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-37"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90069-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90595-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042572"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21067"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005480"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197107152850304"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.11.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-023-01089-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02106"},{"key":"e_1_2_8_13_1","unstructured":"WHO. 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