{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:36:19Z","timestamp":1788212179436,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of the study was to examine the genetic correlation of cluster of differentiation 14 (<jats:italic>CD14<\/jats:italic>) gene polymorphisms with peri\u2010implantitis (PI) predisposition in a Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the case\u2010control study, blood samples were collected from PI patients and healthy individuals (<jats:italic>n<\/jats:italic>\u2009=\u2009120\/group), who were admitted to the Affiliated Hospital of Yangzhou University from 2021 to 2023. One\u2010way analysis of variance (ANOVA) was applied to compare differences of continuous variables among different groups. Genotype and allele distributions of <jats:italic>CD14<\/jats:italic> gene rs2569190 and rs2915863 polymorphisms were analyzed between groups via <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A high percentage of rs2569190 GG genotype or G allele carriers were identified in PI group compared with control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Rs2569190 GG genotype carriers had high risk to develop PI (odds ratio: 2.545, 95% confidence interval: 1.257\u20135.156, <jats:italic>p<\/jats:italic>\u2009=\u2009.009). The rs2569190 AA genotype carriers had the lowest values of gingival index, plaque index, calculus index, peri\u2010implant pocket depth, and clinical attachment level, which were the highest in cases with GG genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rs2569190 polymorphism of <jats:italic>CD14<\/jats:italic> gene was significantly associated with PI predisposition in the Chinese Han population, and the GG genotype and G allele were risk factors for the development of PI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1230","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T12:14:25Z","timestamp":1713356065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association analysis between <i>CD14<\/i> gene polymorphisms and peri\u2010implantitis susceptibility in a Chinese 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