{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:55:28Z","timestamp":1791590128715,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Ankylosing spondylitis (AS) and Beh\u00e7et's disease\u00a0(BD) are distinct inflammatory disorders, but their coexistence is a rare clinical entity. This case sheds light on managing this complex scenario with Janus kinase (JAK) inhibitors.<\/jats:p><\/jats:sec>Case Presentation<\/jats:title>A 42\u2010year\u2010old woman presented with a decade\u2010long history of lower back pain, nocturnal spinal discomfort, recurrent eye issues, oral and genital ulcers, hearing loss, pus formation in the left eye, and abdominal pain. Multidisciplinary consultations and diagnostic tests confirmed AS (HLA\u2010B27 positivity and sacroiliitis) and BD (HLA\u2010B51). Elevated acute\u2010phase markers were observed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This case fulfills diagnostic criteria for both AS and BD, emphasizing their coexistence. Notably, treatment with upadacitinib exhibited promising efficacy, underscoring its potential as a therapeutic option in patients with contraindications for conventional treatments. Our findings illuminate the intricate management of patients presenting with these two diverse systemic conditions and advocate for further exploration of JAK inhibitors in similar cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1242","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T12:04:15Z","timestamp":1712318655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Coexistence of ankylosing spondylitis and Beh\u00e7et's disease: Successful treatment with upadacitinib"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-117X","authenticated-orcid":false,"given":"Krasimir","family":"Kraev","sequence":"first","affiliation":[{"name":"Department of Propaedeutics of Internal Diseases \u201cProf. Dr. Anton Mitov\u201d, Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Uchikov","sequence":"additional","affiliation":[{"name":"Department of Special Surgery, Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozhidar","family":"Hristov","sequence":"additional","affiliation":[{"name":"Second Department of Internal Diseases, Section \u201cGastroenterology\u201d, Medical Faculty Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kraeva","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Medical Faculty Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yordanka","family":"Basheva\u2010Kraeva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical Faculty Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislava","family":"Popova\u2010Belova","sequence":"additional","affiliation":[{"name":"Department of Propaedeutics of Internal Diseases \u201cProf. Dr. Anton Mitov\u201d, Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Sandeva","sequence":"additional","affiliation":[{"name":"Department of Midwifery, Faculty of Public Health Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzhevdet","family":"Chakarov","sequence":"additional","affiliation":[{"name":"Department of Propaedeutics of Surgical Diseases, Section of General Surgery, Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snezhanka","family":"Dragusheva","sequence":"additional","affiliation":[{"name":"Department of Nursing Care, Faculty of Public Health Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Geneva\u2010Popova","sequence":"additional","affiliation":[{"name":"Department of Propaedeutics of Internal Diseases \u201cProf. Dr. Anton Mitov\u201d, Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.6.395"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.6.558"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02238556"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2000.15.1.93"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.9.780"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029189"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.3.258"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"International Study Group for Behcet's disease Criteria for diagnosis of Behcet's disease. Lancet. 1990;335:1078\u20101080.","DOI":"10.1016\/0140-6736(90)92643-V"},{"key":"e_1_2_8_11_1","first-page":"1870","article-title":"Is Beh\u00e7et's disease part of the spondyloarthritis complex?","volume":"24","author":"Olivieri I","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","unstructured":"TulunayA DozmorovMG Ture\u2010OzdemirF et al. Activation of the JAK\/STAT pathway in Behcet's disease. Genes Immun. 2015 Mar;16(2):170\u20105. doi: 10.1038\/gene.2014.64. Epub 2014 Nov 20. 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