{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:11:15Z","timestamp":1780629075511,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The current study aims to explore the relationship between tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) polymorphism and the risk of primary nephrotic syndrome (PNS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 250 PNS patients were selected for this study, as well as 300 volunteers serving as the control group. TNF\u2010\u03b1 polymorphism were assessed using the polymerase chain reaction\u2010restriction fragment length polymorphism method. In addition, a meta\u2010analysis was conducted to analyze previously published literature on this topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were observed in the genotypes frequency or alleles frequency among the study populations. Meta\u2010analysis results revealed a positive association between TNF\u2010\u03b1 rs1800629 polymorphism and allele contrast in African populations (<jats:italic>p<\/jats:italic>\u2009=\u20090), homozygote comparison (<jats:italic>p<\/jats:italic>\u2009=\u2009.007), heterozygote comparison (<jats:italic>p<\/jats:italic>\u2009=\u2009.026), recessive genetic model (<jats:italic>p<\/jats:italic>\u2009=\u2009.011), and dominant genetic model (<jats:italic>p<\/jats:italic>\u2009=\u2009.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TNF\u2010\u03b1 rs1800629 polymorphism does not appear to confer any increased risk for PNS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1278","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:47:46Z","timestamp":1718131666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tumor necrosis factor\u2010\u03b1 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