{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:51:10Z","timestamp":1790628670546,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB037"],"award-info":[{"award-number":["2022CFB037"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012554","name":"Hubei Provincial Department of Education","doi-asserted-by":"publisher","award":["D20201204"],"award-info":[{"award-number":["D20201204"]}],"id":[{"id":"10.13039\/100012554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Astragaloside IV (AS\u2010IV) is the most active monomer in the traditional Chinese herbal medicine <jats:italic>Radix Astragali<\/jats:italic>, which has a wide range of antiviral, anti\u2010inflammatory, and antifibrosis pharmacological effects, and shows protective effects in acute lung injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized the immunofluorescence, flow cytometry, enzyme\u2010linked immunosorbent assay, quantitative reverse transcription\u2010polymerase chain reaction, western blot, and hematoxylin and eosin staining methods to investigate the mechanism of AS\u2010IV in reducing viral pneumonia caused by influenza A virus in A549 cells and BALB\/c mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that AS\u2010IV suppressed reactive oxygen species production in influenza virus\u2010infected A549 cells in a dose\u2010dependent manner, and subsequently inhibited the activation of nucleotide\u2010binding oligomerization domain\u2010like receptor thermal protein domain associated protein 3 inflammasome and Caspase\u20101, decreased interleukin (IL) \u20101\u03b2 and IL\u201018 secretion. In BALB\/c mice infected with Poly (I:C), oral administration of AS\u2010IV can significantly reduce Poly (I:C)\u2010induced acute pneumonia and lung pathological injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AS\u2010IV alleviates the inflammatory response induced by influenza virus in vitro and lung flammation and structural damage caused by poly (I:C) in vivo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1309","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:51:16Z","timestamp":1718131876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Astragaloside IV inhibits inflammation caused by influenza virus via reactive oxygen species\/NOD\u2010like receptor thermal protein domain associated protein 3\/Caspase\u20101 signaling 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