{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:43:36Z","timestamp":1787312616802,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>At present, neonatal hypoxic\u2010ischemic encephalopathy (HIE), especially moderate to severe HIE, is a challenging disease for neonatologists to treat, and new alternative\/complementary treatments are urgently needed. The neuroinflammatory cascade triggered by hypoxia\u2010ischemia (HI) insult is one of the core pathological mechanisms of HIE. Early inhibition of neuroinflammation provides long\u2010term neuroprotection. Plant\u2010derived monomers have impressive anti\u2010inflammatory effects. Aloesin (ALO) has been shown to have significant anti\u2010inflammatory and antioxidant effects in diseases such as ulcerative colitis, but its role in HIE is unclear. To this end, we conducted a series of experiments to explore the potential mechanism of ALO in preventing and treating brain damage caused by HI insult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Hypoxic\u2010ischemic brain damage (HIBD) was induced in 7\u2010day\u2010old Institute of Cancer Research (ICR) mice, which were then treated with 20\u2009mg\/kg ALO. The neuroprotective effects of ALO on HIBD and the underlying mechanism were evaluated through neurobehavioral testing, infarct size measurement, apoptosis detection, protein and messenger RNA level determination, immunofluorescence, and molecular docking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ALO alleviated the long\u2010term neurobehavioral deficits caused by HI insult; reduced the extent of cerebral infarction; inhibited cell apoptosis; decreased the levels of the inflammatory factors interleukin (IL)\u20101\u03b2, IL\u20106, and tumor necrosis factor\u2010\u03b1; activated microglia and astrocytes; and downregulated the protein expression of members in the TLR4 signaling pathway. In addition, molecular docking showed that ALO can bind stably to TLR4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ALO ameliorated HIBD in neonatal mice by inhibiting the neuroinflammatory response mediated by TLR4 signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.1320","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T08:59:27Z","timestamp":1718701167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aloesin ameliorates hypoxic\u2010ischemic brain damage in neonatal mice by suppressing TLR4\u2010mediated neuroinflammation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3569-7831","authenticated-orcid":false,"given":"Liping","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Ji'an Central People's Hospital  Ji'an Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Urinary Surgery Ji'an Central People's Hospital  Ji'an Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Ji'an Central People's Hospital  Ji'an Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Health Science Center Jinggangshan University  Ji'an Jiangxi Province 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