{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:31:52Z","timestamp":1772829112898,"version":"3.50.1"},"reference-count":98,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The identification of novel, easily measurable disease biomarkers might enhance the diagnosis and management of patients with rheumatic diseases (RDs). We conducted a systematic review and meta\u2010analysis of ischemia\u2010modified albumin (IMA), a marker of oxidative stress, acidosis, and ischemia, in RD patients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Web of Science, and Scopus from inception to January 15, 2024. The risk of bias and the certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and GRADE, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 20 studies investigating a total of 1188 RD patients (mean age 45 years, 64% females) and 981 healthy controls (mean age 44 years, 66% females), RD patients had significantly higher IMA concentrations when compared to controls (standard mean difference, SMD\u2009=\u20090.50, 95% CI: 0.18\u22120.83, <jats:italic>p<\/jats:italic>\u2009=\u2009.003; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200992.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; low certainty of evidence). In subgroup analysis, the pooled SMD was significantly different in studies investigating ankylosing spondylitis (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), Beh\u00e7et's disease (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and rheumatoid arthritis (<jats:italic>p<\/jats:italic>\u2009=\u2009.033), but not familial Mediterranean fever (<jats:italic>p<\/jats:italic>\u2009=\u2009.48). Further associations were observed between the pooled SMD and the broad classification of autoimmune and\/or autoinflammatory diseases, the study country, and the method used to measure IMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that IMA is a promising biomarker of oxidative stress, acidosis, and ischemia, as it can effectively discriminate between patients with different types of RDs and healthy controls. Our results warrant confirmation in longitudinal studies of patients with different types of RDs and different ethnicities (PROSPERO registration number: CRD42024509126).<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1324","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T12:59:16Z","timestamp":1718715556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ischemia\u2010modified albumin in rheumatic diseases: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-1412","authenticated-orcid":false,"given":"Arduino A.","family":"Mangoni","sequence":"first","affiliation":[{"name":"Discipline of Clinical Pharmacology, College of Medicine and Public Health Flinders University Adelaide Australia"},{"name":"Department of Clinical Pharmacology Flinders Medical Centre, Southern Adelaide Local Health Network Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Zinellu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1","volume-title":"Handbook of Systemic Autoimmune Diseases","author":"Calle E","year":"2018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030297"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2021.100129"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100952"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.suppl_2.3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh650"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06470-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12809"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2669"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.05.010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05864-8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14270"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216515"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.137"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215920"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113126"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2022.22.e9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.102999"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.007"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00440-y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X221117880"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-022-00217-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04600-7"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.142729"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2020-0727"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.01111"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2902-5"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rap\/rkab106"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2018.1429919"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5079"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2015.034"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310393378"},{"issue":"4","key":"e_1_2_11_35_1","first-page":"966","article-title":"Validity aspects of erythrocyte sedimentation rate and C\u2010reactive protein in ankylosing spondylitis: a literature review","volume":"26","author":"Ruof J","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001756"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1986.tb02232.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.1.79"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9945424"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.11.018"},{"issue":"9","key":"e_1_2_11_41_1","first-page":"BC15","article-title":"Ischemia modified albumin as a marker of oxidative stress in normal pregnancy","volume":"10","author":"Bahinipati J","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12050653"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144205"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097644"},{"issue":"8","key":"e_1_2_11_45_1","article-title":"A comparative study of ischemia\u2010modified albumin: a promising biomarker for early detection of acute coronary syndrome (ACS)","volume":"15","author":"Jawade P","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.333"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.045194"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000213Y.0000000083"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12361"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2019.01410"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9652-9"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.5.2759"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025104"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071306"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203721666200214111816"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.05.086"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114900"},{"key":"e_1_2_11_58_1","article-title":"Distal renal tubular acidosis associated with autoimmune diseases: reports of 3 cases and review of mechanisms","volume":"23","author":"Silveira MAD","year":"2022","journal-title":"Am\u00a0J\u00a0Case Rep"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509841"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092131"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei175"},{"key":"e_1_2_11_62_1","volume-title":"Joanna Briggs Institute Reviewer's Manual","author":"Moola S","year":"2017"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_68_1","first-page":"15","article-title":"Assessing the influence of a single study in the meta\u2010analysis estimate","volume":"47","author":"Tobias A","year":"1999","journal-title":"Stata Technical Bulletin"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00377-8"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.03.016"},{"issue":"6","key":"e_1_2_11_72_1","first-page":"1065","article-title":"Assessment of ischemia\u2010modified albumin levels in patients with rheumatoid arthritis","volume":"60","author":"Leitemperguer M","year":"2014","journal-title":"Clin Lab"},{"issue":"4","key":"e_1_2_11_73_1","first-page":"316","article-title":"Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients (FMF) with attack free period","volume":"39","author":"\u015eahin A","year":"2014","journal-title":"Acta Reumatol Port"},{"issue":"10","key":"e_1_2_11_74_1","first-page":"1609","article-title":"Serum ischemia\u2010modified albumin and malondialdehyde levels and superoxide dismutase activity in patients with fibromyalgia","volume":"60","author":"Toker A","year":"2014","journal-title":"Clin Lab"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.06.007"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2016.62840"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715595744"},{"issue":"4","key":"e_1_2_11_78_1","first-page":"645","article-title":"Increased levels of serum ischemia modified albumin in patients with ankylosing spondylitis","volume":"62","author":"Turkon H","year":"2016","journal-title":"Clin Lab"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-016-0092-4"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2017.71269"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13673"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2019.0001"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12851"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1154-8623"},{"issue":"1","key":"e_1_2_11_85_1","first-page":"97","article-title":"The association of ischemia modified albumin with osteoarthritis progression","volume":"66","author":"Ozler K","year":"2020","journal-title":"Clin Lab"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2018.79139"},{"issue":"1","key":"e_1_2_11_87_1","first-page":"42","article-title":"The relationship of ischemia\u2010modified albumin levels to disease activity scores and HLA\u2010B27 in patients with ankylosing spondylitis","volume":"8","author":"Sertpoyraz FM","year":"2020","journal-title":"North Clin Istanb"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271055"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033221115628"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-022-03138-z"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.078089"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(00)00255-9"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.06.037"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S158513"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030552"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X16648495"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2015.24.4.325"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.006"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.130"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.1324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T09:58:29Z","timestamp":1719568709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.1324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":98,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/iid3.1324"],"URL":"https:\/\/doi.org\/10.1002\/iid3.1324","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1324"}}