{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:23:13Z","timestamp":1783405393774,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prognostic factors of patients with anti\u2010melanoma differentiation\u2010associated gene 5 (MDA5) positive clinically amyopathic dermatomyositis (CADM) and interstitial lung disease (ILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on clinical data of 125 patients with anti\u2010MDA5\u2009+\u2009CADM\u2010ILD collected from 10 branches in eastern China between December 2014 and December 2022. Prognostic factors were analyzed using <jats:italic>\u03c7<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup> test, Log\u2010rank test, COX and logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this cohort, 125 anti\u2010MDA5\u2009+\u2009CADM\u2010ILD patients exhibited a rapidly progressive interstitial lung disease (RPILD) incidence of 37.6%, and an overall mortality rate of 24.8%. One patient was lost to follow\u2010up. After diagnosis of RPILD, a mortality rate of 53.2% occurred in patients died within 3 months, and that of 5.6% appeared in those who survived for more than 3 months. Multiple factor analysis revealed that C\u2010reactive protein (CRP)\u2009\u2265\u200910\u2009mg\/L (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) and recombinant human tripartite motif containing 21 (Ro52) (+) (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) were associated with a higher risk of RPILD in anti\u2010MDA5\u2009+\u2009CADM\u2010ILD patients; CRP\u2009\u2265\u200910\u2009mg\/L (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) and the presence of RPILD (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) were identified as the factors influencing survival time in these patients, while arthritis was the protective factor (<jats:italic>p<\/jats:italic>\u2009=\u20090.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with anti\u2010MDA5\u2009+\u2009CADM\u2010ILD will have a higher mortality rate, and the initial 3 months after diagnosis of RPILD is considered the risk window for the dismal prognosis. Patients with CRP\u2009\u2265\u200910\u2009mg\/L, Ro52 (+) and RPILD may be related to a shorter survival time, while patients complicated with arthritis may present with relatively mild conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1332","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:12:14Z","timestamp":1719486734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic analysis of MDA5\u2010associated clinically amyopathic dermatomyositis with interstitial lung disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0978-8393","authenticated-orcid":false,"given":"Wen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Suqian First People's Hospital of Nanjing Medical University Suqian 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