{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:07:20Z","timestamp":1790381240654,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sirtuin 7 (SIRT7) is pivotal in diverse diseases progression. Importantly, SIRT7 is associated with melanin production. However, whether SIRT7 regulates vitiligo is unclear. Therefore, we aimed to investigate the effects of SIRT7 on pigmentation and the modification of glucose 6\u2010phosphate dehydrogenase (G6PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After knockdown SIRT7 and G6PD, pigmentation of melanocytes was evaluated using commercial kits, immunofluorescence, and Western blot analysis. The succinylation of G6PD mediated by SIRT7 was analyzed using co\u2010immunoprecipitation, immunofluorescence, Western blot analysis, and cycloheximide\u2010chase experiment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that SIRT7 was highly expressed in vitiligo skin lesions. Knockdown of SIRT7 increased tyrosinase activity, melanin content, and the levels of \u03b1\u2010melanocyte\u2010stimulating hormone, MITF, TYR, TRP1, and TRP2. Additionally, SIRT7 directly interacted with G6PD. Silenced SIRT7 promoted the succinylation of G6PD and enhanced its protein stability. G6PD knockdown reversed the effect of reduced SIRT7 expression on melanin production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclsuion<\/jats:title><jats:p>Silencing of SIRT7 promotes pigmentation of melanocytes by succinylating G6PD, suggesting that SIRT7\u2010mediated G6PD desuccinylation may promote vitiligo progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1341","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T11:18:49Z","timestamp":1722597529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mechanism of desuccinylation of G6PD mediated by SIRT7 to promote vitiligo disease progression"],"prefix":"10.1002","volume":"12","author":[{"given":"Yiyun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology Longgang District Maternity &amp; Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College) Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Dermatology Longgang District Maternity &amp; Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College) Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Dermatology Longgang District Maternity &amp; Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College) Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Longgang District Maternity &amp; Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou 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