{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:53:44Z","timestamp":1777100024192,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mecapegfilgrastim, a long\u2010acting\u00a0granulocyte\u2010colony stimulating factor has been approved for reducing the incidence of infection, particularly febrile neutropenia (FN), in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We conducted a multicenter prospective observational study to examine the safety and effectiveness of mecapegfilgrastim in preventing neutropenia in gastrointestinal patients receiving the chemotherapy, including S\u20101\/capecitabine\u2010based regimens or the\u00a0fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI)\/fluorouracil, leucovorin, and oxaliplatin (FOLFOX)\/fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Five hundred and sixty\u2010one gastrointestinal patients from 40 sites across China, between May 2019 and November 2021, were included. The administration of mecapegfilgrastim was prescribed at the discretion of local physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common adverse drug reactions (ADRs) of any grade for all patients was increased white blood cells (2.9%). Grade 3\/4 ADRs were observed for anemia (0.2%), decreased white blood cells (0.2%), and decreased neutrophil count (0.2%). Among the 116 patients who received S\u20101\/capecitabine\u2010based chemotherapy throughout all cycles, ADRs of any grade included anemia (1.7%), myalgia (0.9%), and increased alanine aminotransferase (0.9%). No grade 3\/4 ADRs were observed. In 414 cycles of patients who underwent S\u20101\/capecitabine\u2010based regimens, only one (0.2%) cycle experienced grade 4 neutropenia. In the FOLFIRINOX, FOLFOXIRI, and FOLFOX chemotherapy regimens, grade 4 neutropenia occurred in one (2.7%) of 37 cycles, four (4.7%) of 85 cycles, and two (1.2%) of 167 cycles, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a real\u2010world setting, mecapegfilgrastim has proven effective in preventing severe neutropenia in gastrointestinal patients following chemotherapy. This includes commonly used moderate or high\u2010risk FN regimens or regimens containing S1\/capecitabine, all of which have demonstrated favorable efficacy and safety profiles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1348","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T12:39:35Z","timestamp":1722947975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A multicenter, prospective, non\u2010interventional real\u2010world study to assess the effectiveness of mecapegfilgrastim in preventing neutropenia in patients with gastrointestinal cancer"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1801-5406","authenticated-orcid":false,"given":"Chenyu","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou 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