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Celiac disease (CeD) is a developed immunological condition caused by gluten intolerance and is linked to chronic small intestine enteropathy in genetically predisposed individuals. Dendritic cells (DCs), serving as the bridge between innate and adaptive immunities, can influence immunological responses in CeD through phenotypic alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This review aims to highlight the connection between Trp metabolism and tolerogenic DCs, and the significance of this interaction in the pathogenesis of CeD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It is been recognized that various DC subtypes contribute to the pathogenesis of CeD. Tolerogenic DCs, in particular, are instrumental in inducing immune tolerance, leading to T\u2010reg differentiation that helps maintain intestinal immune tolerance against inflammatory responses in CeD patients and those with other autoimmune disorders. T\u2010regs, a subset of T\u2010cells, play a crucial role in maintaining intestinal immunological homeostasis by regulating the activities of other immune cells. Notably, Trp metabolism, essential for T\u2010reg function, facilitates T\u2010reg differentiation through microbiota\u2010mediated degradation and the kynurenine pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, alterations in Trp metabolism could potentially influence the immune response in CeD, affecting both the development of the disease and the persistence of symptoms despite adherence to a gluten\u2010free diet.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1354","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T12:24:34Z","timestamp":1723811074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The role of tryptophan metabolism and tolerogenic dendritic cells in maintaining immune tolerance: Insights into celiac disease pathogenesis"],"prefix":"10.1002","volume":"12","author":[{"given":"Fatemeh","family":"Asgari","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Clinical Biochemistry, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Khodadoust","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolrahim","family":"Nikzamir","sequence":"additional","affiliation":[{"name":"Student Research Committee, Department of Clinical Biochemistry, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Jahani\u2010Sherafat","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Rezaei Tavirani","sequence":"additional","affiliation":[{"name":"Proteomics Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-1831","authenticated-orcid":false,"given":"Mohammad","family":"Rostami\u2010Nejad","sequence":"additional","affiliation":[{"name":"Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16787"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2006.07.004"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01295-2"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.02.044"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614561668"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1380-z"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/123653"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02783.x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i1.154"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24020945"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01784-2"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30266-y"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.12.006"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.4.1585"},{"issue":"1","key":"e_1_2_14_17_1","first-page":"1","article-title":"Tolerogenic dendritic. 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