{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:31:06Z","timestamp":1784914266419,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This retrospective longitudinal cohort study aimed to explore the best therapeutic regimen and treatment duration of cough variant asthma (CVA) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 314 children with CVA were divided into receive inhaled corticosteroids (ICS) combined with long\u2010acting beta2\u2010agonist (LABA) group, ICS combined with leukotriene receptor antagonists (LTRA) group, ICS monotherapy group and LTRA monotherapy group. All clinical data were statistically analyzed. Logistic regression model was used to compare the advantages and disadvantages of different treatment schemes at each follow\u2010up time point and the best treatment scheme. The Cox proportional hazard regression model based on inverse probability weighting was used to compare the effects of different medication regimens on adverse outcomes with asthma recurrence or progression as the end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) After comprehensive analysis, ICS\u2009+\u2009LABA group was the preferred control regimen for CVA within 8 weeks. After 8 weeks of diagnosis, the efficacy of ICS group or LTRA group was comparable to that of ICS\u2009+\u2009LABA group and ICS\u2009+\u2009LTRA group. (2) The ICS\u2009+\u2009LABA group showed a significant improvement in cough at an early stage, particularly at 4 weeks; the symptoms of ICS\u2009+\u2009LTRA and ICS groups were significantly improved at 36 weeks. The LTRA group alone showed significant improvement at 20 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICS\u2009+\u2009LABA, ICS\u2009+\u2009LTRA, ICS alone and LTRA alone can effectively treat CVA. ICS\u2009+\u2009LABA could improve the symptoms most quickly within 8 weeks after CVA diagnosis, followed by ICS\u2009+\u2009LATR group. After 8 weeks, it can be reduced to ICS alone to control CVA for at least 36 weeks based on the remission of symptoms in children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1357","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T14:28:41Z","timestamp":1723040921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Retrospective, observational study of different medication regimens and outcome in children with cough variant asthma"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-4863","authenticated-orcid":false,"given":"Nannan","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital) Jinan Shandong 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