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Although the exact pathogenesis and etiology of endometriosis is still unclear, it has been shown that it has a chronic inflammatory nature and angiogenesis is also involved in it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This review aims to explore the role of inflammation and angiogenesis in endometriosis and suggest a potential treatment targeting these pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Among the pro\u2010inflammatory cytokines, studies have shown solid roles for interleukin 1\u03b2 (IL\u2010\u03b2), IL\u20106, and tumor necrosis factor \u03b1 (TNF\u2010\u03b1) in the pathogenesis of this condition. Other than inflammation, angiogenesis, the formation of new blood vessels from pre\u2010existing capillaries, is also involved in the pathogenesis of endometriosis. Among angiogenic factors, vascular endothelial growth factor (VEGF), hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1), transforming growth factor \u03b21 (TGF\u2010\u03b21), and matrix metalloproteinases (MMPs) are more essential in the pathogenesis of endometriosis. Interestingly, it has been shown that inflammation and angiogenesis share some similar pathways with each other that could be potentially targeted for treatment of diseases caused by these two processes. Cannabidiol (CBD) is a non\u2010psychoactive member of cannabinoids which has well\u2010known and notable anti\u2010inflammatory and antiangiogenic properties. This agent has been shown to decrease IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1, VEGF, TGF\u03b2, and MMPs in different animal models of diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It seems that CBD could be a possible treatment for endometriosis due to its anti\u2010inflammatory and antiangiogenic activity, however, further studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1370","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T13:58:41Z","timestamp":1723039121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cannabidiol as a possible treatment for endometriosis through suppression of inflammation and angiogenesis"],"prefix":"10.1002","volume":"12","author":[{"given":"Roghayeh","family":"Anvari Aliabad","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamadan University of Medical 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