{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:05:33Z","timestamp":1791756333501,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated clinical and laboratory characteristics of human bocavirus type 1 (HBoV1)\u2010plastic bronchiolitis (PB), <jats:italic>Mycoplasma pneumoniae<\/jats:italic> (MP)\u2010associated plastic bronchitis (PB) and MP\u2010NPB in children, highlighting inflammation, coagulation, and bronchoscopic needs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on preschool children with PB during HBoV1 or MP infection were collected, comparing MP\u2010PB to severe <jats:italic>Mycoplasma pneumoniae pneumonia<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Compared with the MP\u2010PB group, the HBoV1\u2010PB group, with younger children, had significantly milder clinical symptoms but higher WBC counts (<jats:italic>p<\/jats:italic>\u2009=\u2009.028). The MP\u2010PB group exhibited notably elevated Fibrinogen (<jats:italic>p<\/jats:italic>\u2009=\u2009.045) and <jats:sc>d<\/jats:sc>\u2010dimer levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). When contrasting the MP\u2010PB with the MP\u2010NPB group, children in MP\u2010PB group still had higher levels of <jats:sc>d<\/jats:sc>\u2010dimer and increased inflammatory indicators such as C\u2010reactive protein, procalcitonin, lactate dehydrogenase, and interleukin\u20106, which were significantly elevated compared with the MP\u2010NPB group. MP\u2010PB showed a higher prevalence of plastic bronchial casts in lower lobes (<jats:italic>p<\/jats:italic>\u2009=\u2009.016) and a dominance of neutrophils in BALF cytology. Additionally, children in the MP\u2010PB group tended to undergo a greater number of bronchoscopies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study identifies key differences in plastic bronchitis in children due to HBoV1 and MP, highlighting HBoV1's milder inflammation in younger kids and MP's link to severe inflammatory and coagulation responses, guiding clinical diagnosis and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.1373","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T12:41:01Z","timestamp":1723812061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Distinct clinical characteristics of bocavirus and <i>Mycoplasma pneumoniae<\/i> infection in children plastic 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