{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:03:30Z","timestamp":1789733010453,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G1100211\/1"],"award-info":[{"award-number":["G1100211\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Suppressor of cytokine signaling 3 (SOCS3) is a tumour suppressor, limiting intestinal epithelial cell (IEC) proliferation in acute inflammation, and tumour growth, but little is known regarding its role in mucosal homeostasis. Resistance to the intestinal helminth <jats:italic>Trichuris muris<\/jats:italic> relies on an \u201cepithelial escalator\u201d to expel the parasite. IEC turnover is restricted by parasite\u2010induced indoleamine 2,3\u2010dioxygenase (IDO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice with or without conditional knockout of SOCS3 were infected with <jats:italic>T. muris<\/jats:italic>. Crypt depth, worm burden, and proliferating cells and IDO were quantified. SOCS3 knockdown was also performed in human IEC cell lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic <jats:italic>T. muris<\/jats:italic> infection increased expression of SOCS3 in wild\u2010type mice. Lack of IEC SOCS3 led to a modest increase in epithelial turnover. This translated to a lower worm burden, but not complete elimination of the parasite suggesting a compensatory mechanism, possibly IDO, as seen in SOCS3 knockdown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report that SOCS3 impacts on IEC turnover following <jats:italic>T. muris<\/jats:italic> infection, potentially through enhancement of IDO. IDO may dampen the immune response which can drive IEC hyperproliferation in the absence of SOCS3, demonstrating the intricate interplay of immune signals regulating mucosal homeostasis, and suggesting a novel tumour suppressor role of SOCS3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.171","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T04:06:42Z","timestamp":1494907602000},"page":"336-345","source":"Crossref","is-referenced-by-count":10,"title":["Intestinal epithelial suppressor of cytokine signaling 3 (SOCS3) impacts on mucosal homeostasis in a model of chronic inflammation"],"prefix":"10.1002","volume":"5","author":[{"given":"Elisabeth J.","family":"Shaw","sequence":"first","affiliation":[{"name":"Division of Biomedical and Life Sciences Faculty of Health and Medicine Lancaster University Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Sciences Faculty of Health and Medicine Lancaster University Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayde","family":"Whittingham\u2010Dowd","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Sciences Faculty of Health and Medicine Lancaster University Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Sciences Faculty of Health and Medicine Lancaster University Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Else","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine, and Health Manchester University Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6605-9609","authenticated-orcid":false,"given":"Rachael J.","family":"Rigby","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Sciences Faculty of Health and Medicine Lancaster University Lancaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210286"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2232790100"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.025"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208818"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00214.2014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410992200"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1492-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00328.2004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140488"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.4.471"},{"issue":"8","key":"e_1_2_8_13_1","first-page":"12009","article-title":"IL\u20106\/STAT3\/SOCS3 signaling pathway playing a regulatory role in ulcerative colitis carcinogenesis","volume":"8","author":"Chen Y.\u2010Y.","year":"2015","journal-title":"Int. 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