{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:17:52Z","timestamp":1791908272481,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_141039\/1"],"award-info":[{"award-number":["31003A_141039\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260252"],"award-info":[{"award-number":["81260252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260452"],"award-info":[{"award-number":["81260452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1303222"],"award-info":[{"award-number":["U1303222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      The growth potential of the tumor\u2010like\n                      <jats:italic>Echinococcus multilocularis<\/jats:italic>\n                      metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature\/function of the periparasitic host immune\u2010mediated processes. Previous studies had shown that regulatory T cells (Tregs) become gradually up\u2010regulated in the course of both chronic human and murine AE. Thus we now tackled the role of FoxP3\n                      <jats:sup>+<\/jats:sup>\n                      Tregs and FoxP3\n                      <jats:sup>+<\/jats:sup>\n                      \u2010Treg\u2010regulated immune response in contributing to the control of this helminthic infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The infection outcome in\n                      <jats:italic>E. multilocularis<\/jats:italic>\n                      \u2010infected DEREG mice was measured upon determining parasite load (wet weight of parasitic metacestode tissue). Flow cytometry and qRT\u2010PCR were used to assess Treg, Th17\u2010, Th1\u2010, Th2\u2010type immune responses and antigen presenting cell activation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We showed that\n                      <jats:italic>E. multilocularis<\/jats:italic>\n                      \u2010infected DEREG\u2010mice treated with DT (as compared to infected control DEREG\u2010mice without DT application) exhibited a significantly lower parasite load, associated with a persisting capacity of co\u2010stimulation, and an increased Th1\/Th17\u2010polarization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      FoxP3\n                      <jats:sup>+<\/jats:sup>\n                      Tregs appear as one of the key players in immune regulatory processes favoring (i) metacestode survival by inhibiting the maturation potential of co\u2010stimulatory activity and (ii) T cell exhaustion (suppressing Th1\/Th17\u2010type immune responses). We showed as well that prospectively, targeting FoxP3\n                      <jats:sup>+<\/jats:sup>\n                      Tregs could be an option to develop an immunotherapy against AE.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.181","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T01:12:43Z","timestamp":1497575563000},"page":"435-447","source":"Crossref","is-referenced-by-count":44,"title":["Depletion of FoxP3\n                    <sup>+<\/sup>\n                    Tregs improves control of larval\n                    <i>Echinococcus multilocularis<\/i>\n                    infection by promoting co\u2010stimulation and Th1\/17 immunity"],"prefix":"10.1002","volume":"5","author":[{"given":"Junhua","family":"Wang","sequence":"first","affiliation":[{"name":"Vetsuisse Faculty, Department of Infectious Diseases and Pathobiology, Institute of Parasitology University of Bern Bern Switzerland"},{"name":"State Key Lab Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"FACSLab, c\/o Institute of Pathology University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyong","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Lab Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Siffert","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, Department of Infectious Diseases and Pathobiology, Central Animal Facilities 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