{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:14:16Z","timestamp":1781820856407,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009447","name":"Leukemia and Lymphoma Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010137000"],"award-info":[{"award-number":["MOP\u2010137000"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dickkopf\u20101 (DKK1) is a soluble protein and antagonist of the Wnt\/\u03b2\u2010catenin signaling pathway. DKK1 is found elevated in serum from patients affected with various types of cancers and in some instances, it is considered a diagnostic and prognostic biomarker. Elevated serum levels of DKK1 have also been detected in animal models of chronic inflammatory diseases. Previous work from our laboratory has demonstrated upregulation of DKK1 in cells and mouse models of the bone marrow failure (BMF) and cancer\u2010prone disease Fanconi anemia (FA). The present study aimed to investigate whether DKK1 blood levels in patients are associated with FA or inflammatory responses to acute infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma samples were collected from 58 children admitted to the Centre M\u00e8re\u2010Enfant Soleil du Centre Hospitalier de Qu\u00e9bec\u2010Universit\u00e9 Laval with signs of acute infections. Blood plasma specimens were also collected from healthy blood donors at the H\u00e9ma\u2010Qu\u00e9bec blood donor clinic. Plasmas from patients diagnosed with FA were also included in the study. DKK1 levels in blood plasmas were assessed by standard ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with acute infections showed dramatically high levels of DKK1 (6072\u2009\u00b1\u2009518\u2009pg\/ml) in their blood compared to healthy blood donors (1726\u2009\u00b1\u200995\u2009pg\/ml). No correlations were found between DKK1 levels and C reactive protein (CRP) concentration, platelet numbers, or white blood cell counts. Patients with FA showed higher DKK1 plasma levels (3419\u2009\u00b1\u2009147.5\u2009pg\/ml) than healthy blood donors (1726\u2009\u00b1\u200995\u2009pg\/ml) but significantly lower than patients with acute infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that blood DKK1 is elevated in response to infections and perhaps to inflammatory responses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.232","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T12:19:19Z","timestamp":1532089159000},"page":"428-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Elevated blood levels of Dickkopf\u20101 are associated with acute infections"],"prefix":"10.1002","volume":"6","author":[{"given":"Melody","family":"Mazon","sequence":"first","affiliation":[{"name":"Centre Hospitalier de Qu\u00e9bec\u2010Universit\u00e9 Laval Research Center 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