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We analyzed the serial changes in the production of feeding type\u2010related egg\u2010 and milk\u2010specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Allergen\u2010specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Formula and mixed feeding were associated with a rapid increase in cow's milk allergen\u2010specific immunoglobulins and feeding type\u2010related significant differences in casein\u2010specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin\u2010specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low\u2010 or high\u2010affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin\u2010specific IgG1 levels, detectable IgG2, and low\u2010affinity IgE, while the other had low ovalbumin\u2010specific IgG1 levels, undetectable IgG2, and high levels of high\u2010affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Feeding practice\u2010related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high\u2010affinity IgE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.245","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T04:39:05Z","timestamp":1552365545000},"page":"74-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Trajectories of class\u2013switching\u2010related egg and cow's milk allergen\u2010specific immunoglobulin isotype formation and its modification by eczema with low\u2010 and high\u2010affinity immunoglobulin E during early infancy"],"prefix":"10.1002","volume":"7","author":[{"given":"Makoto","family":"Irahara","sequence":"first","affiliation":[{"name":"Division of Enzyme Chemistry Institute for Enzyme Research, Tokushima University Tokushima Japan"},{"name":"Department of Pediatrics Graduate School of Medicine, Tokushima 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