{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:59:45Z","timestamp":1776830385873,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T00:00:00Z","timestamp":1555718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>Trichosporon asahii<\/jats:italic> is an emerging cause of systemic fungal infection in an immunocompromised host. Several life threatening disseminated <jats:italic>T. asahii<\/jats:italic> infection in single solid organ (liver or kidney) transplant recipients, in neutropenic and hematological malignancy patients have been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation (Methods and Results)<\/jats:title><jats:p>A 49\u2010year old gentleman who underwent simultaneous living\u2010donor liver transplantation (donor sister) and kidney transplant (donor wife) developed fever and subsegmental patchy consolidation with right sided pleural effusion on fourth postoperative day. Central line blood stream infection was suspected. Blood culture grew creamy white colonies of <jats:italic>T. asahii<\/jats:italic> on blood agar with characteristic dirty\u2010green colonies on CHROMagar. Laboratory analysis of pleural fluid also revealed budding yeast cells identified as <jats:italic>T. asahii<\/jats:italic>. Microscopy of the isolates showed hyphae, arthroconidia, and blastospores. The isolates were identified as <jats:italic>T. asahii<\/jats:italic> by VITEK MS which uses matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight (MALDI\u2010TOF) technology. Initially liposomal amphotericin B and micafungin was initiated, but due to lack of clinical and microbiological response, patient was switched to voriconazole. Simultaneously, tacrolimus doses were reduced to one\u2010third in view of interaction with voriconazole. Subsequently, patient improved with resolution of fever and microbiological cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first case report of disseminated <jats:italic>T. asahii<\/jats:italic> infection in a combined liver\u2010kidney transplant recipient successfully treated with voriconazole. Azole antifungal are the promising drug of choice for systemic <jats:italic>T. asahii<\/jats:italic> infection. Drug interactions should be considered while using these antifungal agents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.250","type":"journal-article","created":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T06:38:32Z","timestamp":1555828712000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Disseminated <i>Trichosporon asahii<\/i> infection in a combined liver\u2010kidney transplant recipient successfully treated with voriconazole"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-8714","authenticated-orcid":false,"given":"Ranjit","family":"Sah","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Medanta The Medicity Gurgaon Haryana India"},{"name":"Institute of Medicine Tribhuvan University Teaching Hospital Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arbindra singh","family":"Soin","sequence":"additional","affiliation":[{"name":"Institute of Liver Transplantation and regenerative Medicine Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sony","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teena","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Department of Microbiology Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Medanta The Medicity Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,20]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-4958.170802"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1818-1828.2005"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(99)90015-4"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/322640"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200202000-00018"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/787689"},{"key":"e_1_2_8_1_8_1","first-page":"651315","article-title":"Two case presentations infected by Trichosporon asahii and treated with voriconazole successfully","volume":"2015","author":"Tanyildiz HG","year":"2015","journal-title":"Case Rep Infect Dis"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050221"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00003-11"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12360"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.6.1985-1993.1999"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2018.50.2.138"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/599614"},{"issue":"3","key":"e_1_2_8_1_15_1","first-page":"226","article-title":"Trichosporon asahii. 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