{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:41:18Z","timestamp":1784371278086,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonsteroidal anti\u2010inflammatory drug (NSAID) exacerbated respiratory disease (N\u2010ERD) is a triad with asthma, chronic rhinosinusitis with nasal polyps, and NSAID intolerance. Uncontrolled N\u2010ERD forms a major public health problem due to frequent and difficult\u2010to\u2010treat exacerbations and\/or requiring putatively frequent endoscopic sinus surgeries (ESS). Our aim was to study factors affecting control of N\u2010ERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective patient record data (patient characteristics, prior sinus surgeries, follow\u2010up data in 2020) from 167 N\u2010ERD patients undergoing consultation at three tertiary hospitals from 2001 to 2017 was used. Outcome measurements reflecting uncontrolled N\u2010ERD were revision ESS, corticosteroids\/biological therapy, and antibiotic courses during 2016\u20132020. Associations were analyzed by using nonparametric tests, Cox's proportional hazard, and binary logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nasal polyp eosinophilia increased the risk of revision surgery during the follow\u2010up (adjusted hazard ratio [aHR] 3.21, confidence interval 1.23\u20138.38). Also baseline oral corticosteroids (OCS; HR, 1.73, 1.04\u20132.89) and baseline surgery without total ethmoidectomy increased the risk of revision ESS (HR, 2.17, 1.07\u20134.42) in unadjusted models. In addition, both baseline OCS (adjusted odds ratio [aOR] 2.78, 1.23\u20136.26) and a history of \u22654 previous ESS (aOR, 2.15, 0.98\u20134.70) were associated with the use of OCS\/biological therapy during the follow\u2010up, but not with high number of antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nasal polyp eosinophilia, baseline OCS, and a history of recurrent ESS predict uncontrolled N\u2010ERD. These factors might be clinically useful in risk\u2010estimation of uncontrolled disease and for organizing follow\u2010ups. Prospective cohort studies with larger sample size are needed to further study the factors affecting the upper airway control of N\u2010ERD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.347","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T07:46:02Z","timestamp":1609919162000},"page":"80-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Factors affecting upper airway control of NSAID\u2010exacerbated respiratory disease: A real\u2010world study of 167 patients"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-1227","authenticated-orcid":false,"given":"Annina","family":"Lyly","sequence":"first","affiliation":[{"name":"Inflammation Center, Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Helsinki and 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