{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:45:10Z","timestamp":1791567910977,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09273"],"award-info":[{"award-number":["18K09273"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to evaluate the relationship between chronic endometritis (CE) and a personalized window of implantation (WOI), identified by results of endometrial receptivity analysis (ERA), and pregnancy outcomes following embryo transfer (ET) based on the ERA outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The single\u2010center, cross\u2010sectional study was designed. The study population consisted of 101 infertile women who underwent endometrial sampling between June 2018 and February 2020. We recruited 88 patients who underwent ERA testing and immunohistochemistry of the plasma cell marker CD138 to diagnose CE within 3 months of testing. Subjects were divided into three groups as follows: 33 without CE (non\u2010CE group); 19 with untreated CE at ERA testing (CE group); and 36 successfully treated for CE before ERA testing (cured\u2010CE group). CE diagnosis was defined as \u22655 CD138\u2010positive plasma cells per 10 random stromal areas at \u00d7400 magnification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In non\u2010CE, CE, and cured\u2010CE groups, the numbers of CD138\u2010positive cells were 0.7\u2009\u00b1\u20091.0, 28.5\u2009\u00b1\u200930.4, and 1.3\u2009\u00b1\u20091.3, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The rates of \u201creceptive\u201d endometrium in non\u2010CE and cured\u2010CE groups were 57.6% (19 women) and 50.0% (18 women), respectively; however, in the CE group, this rate was significantly lower than the other two groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.009) at only 15.8% (3 women). After CE were treated prior or posterior to the ERA test in cured\u2010CE or CE groups, the clinical pregnancy rates at the first ET in non\u2010CE, CE, and cured\u2010CE groups were 77.8% (21\/27 cycles), 22.2% (4\/18 cycles), and 51.7% (15\/29 cycles), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CE had detrimental effects on the individual WOI, leading to embryo\u2013endometrial asynchrony; therefore, diagnosis and treatment of CE should be done before ERA testing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.354","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T08:06:22Z","timestamp":1600934782000},"page":"650-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Impact of chronic endometritis on endometrial receptivity analysis results and pregnancy outcomes"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-9159","authenticated-orcid":false,"given":"Keiji","family":"Kuroda","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine and Implantation Research Sugiyama Clinic Shinjuku  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Implantation Research Sugiyama Clinic Shinjuku  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Implantation Research Sugiyama Clinic Shinjuku  Tokyo 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