{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:31:56Z","timestamp":1782484316609,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies have shown an association between cesarean section (CS) and increased prevalence of childhood allergic diseases. While these observations have been consistent in industrialized countries, evidence from developing countries is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between the mode of delivery and allergic diseases in children aged 3\u201312 years in Quito, Ecuador.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, parents were surveyed using an anonymous, standardized questionnaire from the International Study of Asthma and Allergies in Childhood project to assess the presence of asthma, allergic rhinitis, atopic dermatitis, and food allergies in their children. The children's age, sex, birthplace, delivery mode (CS\/vaginal), socioeconomic status, and ethnicity were recorded. Other parameters included gestational age, breastfeeding, smoking status during pregnancy, and parental allergic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for confounding factors, children delivered via CS were found to have a higher risk of wheezing (odds ratio [OR]\u2009=\u20094.12, 95% confidence interval [CI]: 1.43\u201311.89), physician\u2010diagnosed asthma (OR\u2009=\u200924.06; 95% CI: 1.98\u2013292.3), and pimples, or eczema with the itching for 6 months (OR\u2009=\u20092.65; 95% CI: 1.06\u20136.61) than children delivered vaginally. No association was found between the delivery mode and rhinitis or food allergies. After stratifying by socioeconomic status, CS was only associated with allergic disorders in children of medium\/high socioeconomic backgrounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As seen in industrialized settings, children born by CS in nonindustrialized countries have an increased risk of developing allergic disorders including asthma and dermatitis, compared to those delivered vaginally.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.368","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T05:43:52Z","timestamp":1604123032000},"page":"763-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cesarean section and risk of allergies in Ecuadorian children: A cross\u2010sectional study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-9877","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Gorris","sequence":"first","affiliation":[{"name":"School of Medicine Universidad San Francisco de Quito Quito Ecuador"},{"name":"Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"},{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-7209","authenticated-orcid":false,"given":"Gabriela","family":"Bustamante","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad San Francisco de Quito Quito Ecuador"},{"name":"Program in Health Disparities Research University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-790X","authenticated-orcid":false,"given":"Katharina A.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8238-2561","authenticated-orcid":false,"given":"Tamar","family":"Kinaciyan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-4173","authenticated-orcid":false,"given":"Gerhard J.","family":"Zlabinger","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-5-S3-S212"},{"key":"e_1_2_11_3_1","volume-title":"WAO\u2010White\u2010Book\u2010on\u2010Allergy","author":"Pawankar R","year":"2011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.045"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.suppl_1.S2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.111"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207199"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00008114"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148343"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12324"},{"key":"e_1_2_11_11_1","first-page":"460","article-title":"Risk factors for asthma among primary school children in Baghdad, Iraq","volume":"26","author":"Al\u2010Kubaisy W","year":"2005","journal-title":"Saudi Med J"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-12-17"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-14-15"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200225"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3347"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/birt.12421"},{"key":"e_1_2_11_17_1","unstructured":"MSP Ministerio de Salud P\u00fablica del Ecuador.\u00a02017.http:\/\/www.salud.gob.ec\/direccion-nacional-de-vigilancia-epidemiologica\/. 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