{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:31:06Z","timestamp":1784194266810,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The coronavirus disease (COVID\u201019), during its course, may involve several organs, including the skin with a petechial skin rash, urticaria and erythematous rash, or varicella\u2010like eruption, representing an additional effect of the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection, as commonly observed in other viral diseases. Considering that symptomatic patients with COVID\u201019 generally undergo multidrug treatments, the occurrence of a possible adverse drug reaction presenting with cutaneous manifestations should be contemplated. Pleomorphic skin eruptions occurred in a 59\u2010year\u2010old Caucasian woman, affected by a stable form of chronic lymphocytic leukemia, and symptomatic SARS\u2010CoV\u20102 infection, treated with a combination of hydroxychloroquine sulfate, darunavir, ritonavir, sarilumb, omeprazole, ceftriaxone, high\u2010flow oxygen therapy devices, filgrastim (Zarzio\u00ae) as a single injection, and enoxaparin. The patient stopped all treatment but oxygen and enoxaparin were continued and the patient received a high\u2010dose Desametasone with complete remission of dermatological impairment in 10 days. It is very important to differentially diagnose COVID\u201019 disease\u2010related cutaneous manifestations, where is justified to continue the multidrug antiviral treatment, from those caused by an adverse drug reaction, where it would be necessary to identify the possible culprit drug and to start appropriate antiallergic treatment.<\/jats:p>","DOI":"10.1002\/iid3.382","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T08:06:44Z","timestamp":1620115604000},"page":"617-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pleomorphicskin eruptions in a COVID\u201019 affected patient: Case report and review of the literature"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-9168","authenticated-orcid":false,"given":"Enrico","family":"Scala","sequence":"first","affiliation":[{"name":"Covid Unit Istituto Dermopatico 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