{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:13:32Z","timestamp":1777497212046,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our previous study has developed a four\u2010gene model involving <jats:italic>IL13<\/jats:italic> rs20541, <jats:italic>IL4<\/jats:italic> rs2243250, <jats:italic>ADRB2<\/jats:italic> rs1042713, and <jats:italic>FCER1B<\/jats:italic> rs569108 associated with asthma and atopy in Chinese Han children. However, whether the gene model is associated with allergies in early life has yet to be determined. This study aimed to apply the gene model in a birth cohort to investigate its associations with the development of allergic diseases in Chinese Han toddlers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five hundred and ninety\u2010seven\u00a0children from a birth cohort completing 2\u2010year follow\u2010up were included. Epidemiologic information and cord blood were collected. Children were genotyped for the above polymorphisms and divided into high or low genetic risk groups based on the genotypes. Subjects were followed at 6, 12, and 24 months, with information on allergic diseases collected via standard questionnaires and assessed by specialists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and eighty\u2010four\u00a0children were divided into a high\u2010risk group and 313 into a low\u2010risk group. Between the two groups, a significant difference was only found in delivery mode among all the subject characteristics (<jats:italic>p<\/jats:italic>\u2009=\u2009.025). After stratification for delivery mode, children at high risk were more likely to develop eczema (relative risk [RR]\u2009=\u20091.46, <jats:italic>p<\/jats:italic>\u2009=\u2009.040) over 2 years of follow\u2010up compared with those at low risk. No significant associations were found between genetic risk and food allergy, wheezing and allergic rhinitis (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The gene model was significantly associated with the development of eczema in Chinese Han toddlers. Long\u2010term follow\u2010up along with functional and replication studies on the gene model are still needed in future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.385","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T11:49:31Z","timestamp":1607168971000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of a four\u2010gene model with allergic diseases: Two\u2010year follow\u2010up of a birth cohort study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4033-967X","authenticated-orcid":false,"given":"Li","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Ministry of Education\u2010Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoxu","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-1611","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education\u2010Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiao","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Shanghai Tonxin Pediatric Clinic Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.07.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2013.08.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364284"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1635"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9903128"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00869.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23322"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0272"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"e_1_2_8_11_1","first-page":"352","article-title":"A questionnaire based survey on prevalences of asthma, allergic rhinitis and eczema in five Chinese cities (ISAAC study)","volume":"36","author":"Chen YZ","year":"1998","journal-title":"Chin J Pediatr"},{"key":"e_1_2_8_12_1","first-page":"5","article-title":"Prevalence of food allergy in children under 2 years of age in three cities in China","volume":"50","author":"Chen J","year":"2012","journal-title":"Chin J Pediatr"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814561600"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12336"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.12.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01712.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200502"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085458"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.2926"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301019"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080231"},{"key":"e_1_2_8_24_1","first-page":"67","article-title":"The \u2010590C\/TIL4 single\u2010nucleotide polymorphism as a genetic factor of atopic allergy","volume":"1","author":"Guia RM","year":"2010","journal-title":"Int J Mol Epidemiol Genet"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12200"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt093"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13356"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00053"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12824"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.385","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T18:10:01Z","timestamp":1744395001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,5]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/iid3.385"],"URL":"https:\/\/doi.org\/10.1002\/iid3.385","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,5]]},"assertion":[{"value":"2020-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}