{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:41:08Z","timestamp":1789620068096,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010011","name":"Jiangsu Postdoctoral Research Foundation","doi-asserted-by":"publisher","award":["2020Z188"],"award-info":[{"award-number":["2020Z188"]}],"id":[{"id":"10.13039\/501100010011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770556"],"award-info":[{"award-number":["81770556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The pathogenesis of inflammatory bowel disease (IBD) has not yet been clarified and is closely related to several pro\u2010inflammatory factors. MicroRNA\u2010233 (miR\u2010223) might be involved in the development of IBD; however, the mechanism underlying its pathogenesis is unclear. In this study, we attempted to determine the role of miR\u2010223 in dextran sodium sulfate (DSS)\u2010induced colitis and explore the involvement of the IL\u20106\/STAT3 pathway in the development of intestinal mucosal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Except control (WT) group, male C57BL\/6 mice were provided DSS, then treated for with miR\u2010223 agomir or antagomir including DSS group, DSS\u2009+\u2009miR\u2010223 agomir (DSS\u2009+\u2009A) group, and DSS\u2009+ miR\u2010223 antagomir (DSS\u2009+\u2009AN) group. The colitis symptoms were observed, the disease activity index (DAI) score were recorded daily, and colonic inflammation was evaluated by histopathological scoring. The expression of myeloperoxidase (MPO), cytokines and IL\u20106\/STAT3 pathway\u2010related proteins were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>miR\u2010223 expression in the terminal ileum and colon was increased in the DSS group compared with the WT group. Colitis symptoms were significantly alleviated in the DSS\u2009+\u2009A group and exacerbated in the DSS\u2009+\u2009AN group after administration of the miR\u2010223 agomir and antagomir, respectively. MPO, tumor necrosis factor\u2010\u03b1, IL\u20106, and IL\u201017 were decreased and IL\u201010 was increased in the DSS\u2009+\u2009A group, but these changes were reversed in the DSS\u2009+\u2009AN group. Gp130, p\u2010STAT3, Bcl\u20102, and Bcl\u2010xl in the colon declined in the DSS\u2009+\u2009A group, but these levels increased in the DSS\u2009+\u2009AN group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The upregulation of miR\u2010223 by agomir administration alleviated colonic inflammation in a DSS\u2010induced colitis model, which was likely mediated by inhibiting the production of pro\u2010inflammatory cytokines via the IL\u20106\/STAT3 signaling pathway. These findings provide evidence that miR\u2010223 might have potential therapeutic implications in IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.395","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T08:52:10Z","timestamp":1608281530000},"page":"319-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["miR\u2010223 improves intestinal inflammation through inhibiting the IL\u20106\/STAT3 signaling pathway in dextran sodium sulfate\u2010induced experimental colitis"],"prefix":"10.1002","volume":"9","author":[{"given":"Juanjuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery Jinling Hospital  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery Jinling Hospital  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binlin","family":"Da","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery Jinling Hospital  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-3161","authenticated-orcid":false,"given":"Qiurong","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital Nanjing 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