{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:56:08Z","timestamp":1787068568743,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The low frequency of ectopic germinal center in labial salivary glands of patients with human T\u2010cell leukemia virus type 1 (HTLV\u20101) antibody\u2010positive Sj\u00f6gren's syndrome (SS) suggests that HTLV\u20101 has some effects on follicular dendritic cells (FDCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used flow cytometry, immunofluorescence, and enzyme\u2010linked immunosorbent assays (ELISAs) to investigate the direct effect of HTLV\u20101 on B\u2010cell activating factors produced by established FDC like cells obtained from excised human tonsils. We then measured the serum B\u2010cell activating factor (BAFF) and C\u2010X\u2010C motif ligand (CXCL) 13 concentrations of the HTLV\u20101\u2010seropositive SS patients and the HTLV\u20101\u2010seronegative SS patients by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 31 isolated specimens, 22 showed morphological characteristics of FDCs. Day 2\u2010cultured specimens showed expressions of CD14, CD23, CD40, intracellular adhesion molecule\u20101 (ICAM\u20101), and vascular cell adhesion molecule\u20101. After 2 weeks, 12 of these specimens expressed ICAM\u20101, FDC, and fibroblast cell marker. Intracellular BAFF and CXCL13 were constitutively expressed regardless of stimulation. After direct coculture with the HTLV\u20101\u2010infected T\u2010cell line HCT\u20105 or MT\u20102, the BAFF and CXCL13 expressions on the FDC\u2010like cells were decreased in accord with the increased number of HCT\u20105 and MT\u20102 cells with styliform change and without HTLV\u20101 Gag protein expression. Interferons upregulated the concentration of BAFF (but not CXCL13) in the culture supernatant, which showed a declining trend under the presence of HCT\u20105 or MT\u20102. The serum concentrations of BAFF and CXCL13 in the HTLV\u20101\u2010seropositive SS patients were lower than those of the HTLV\u20101 seronegative SS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HTLV\u20101 partially inhibited the BAFF and CXCL13 expressions of established FDC\u2010like cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.432","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T06:21:08Z","timestamp":1620109268000},"page":"777-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inhibitory effect of HTLV\u20101 infection on the production of B\u2010cell activating factors in established follicular dendritic cell\u2010like cells"],"prefix":"10.1002","volume":"9","author":[{"given":"Ayuko","family":"Takatani","sequence":"first","affiliation":[{"name":"Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-6348","authenticated-orcid":false,"given":"Hideki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki 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