{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:50:09Z","timestamp":1787496609655,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071569"],"award-info":[{"award-number":["82071569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nasal nitric oxide (nNO) levels in allergic rhinitis (AR), healthy people or nonallergic rhinitis (NAR) have shown contradicting results in previous studies. By meta\u2010analysis, we reviewed studies that measured nNO in AR patients to assess nNO's ability to discriminate AR from healthy people or NAR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Cochrane, Embase, Ovid, Web of Science, Wanfang Data, CNKI until December 15, 2020. Differences were expressed as standardized mean differences (SMD) with 95% confidence interval (CI), by random\u2010effects method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 10 original studies with 561 AR patients, 327 healthy controls, 123 NAR patients were included in the narrative synthesis and 9 studies in the meta\u2010analysis. nNO in AR was significantly increased compared with healthy controls (SMD: 0.989; 95% CI: 0.402, 1.576;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001) or NAR (SMD: 0.680; 95% CI: 0.101, 1.259;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). However, subgroup analysis based on measuring process and patient characteristics showed that no significant differences were detected in nNO between AR patients with nasal polyps or sinusitis or marked ostial obstruction and healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>nNO is a potential indicator for recognizing AR. Nasal polyps, sinusitis and marked ostial obstruction should be considered before nNO is applied to detect AR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.439","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T04:37:54Z","timestamp":1620275874000},"page":"635-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nasal nitric oxide testing for allergic rhinitis patients: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Bingbing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"},{"name":"Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"},{"name":"Shandong Key Laboratory of Infectious Respiratory Disease  Jinan Shandong China"},{"name":"Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences)  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"},{"name":"Department of Pulmonary and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuojuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"},{"name":"Department of Pulmonary and Critical Care Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong China"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 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