{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:12:20Z","timestamp":1760890340878,"version":"3.37.3"},"reference-count":3,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Case report of a 21\u2010year\u2010old female developing non\u2010radiographic axialspondyloarthritis in the setting of a preceding severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. We felt this was a unique case as some cases of psoriatic arthropathy and reactive arthropathy but none, to our knowledge of non\u2010radiographic axial spondyloarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Twenty one\u2010year\u2010old female presented in June 2020 with inflammatory symptoms with general work\u2010up per primary care provider being negative. Upon further work\u2010up per Rheumatology, felt to have inflammatory back pain with X\u2010rays of SI joints showing grade II sclerosis. Further work\u2010up including magnetic resonance imaging was positive demonstrating bone edema and erosions of SI joint. This prompted further investigation and she had had some vague symptoms of SARS\u2010CoV\u20102 several months prior including loss of smell, fatigue, and malaise. SARS\u2010CoV\u20102 semiquanitative antibodies where done that where high positive. She was treated with cetrolizumab and had prompt improvement over the course of the next week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>Mechanism of SARS\u2010CoV\u20102 triggering autoimmunity is still unknown at this time. However, it is important that insights be gained into the type of disease that can be triggered by this infection. As the pandemic continues to rage on, Rheumatologist need to be increasing aware that patients presenting with various forms of inflammatory arthritis may be triggered by an antecedent SARS\u2010CoV\u20102 infection. Following these cases may help to determine how they differ from other forms of inflammatory arthropathy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.448","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T15:20:51Z","timestamp":1620832851000},"page":"628-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The first non\u2010radiographic axial spondyloarthrits with COVID\u201019"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-9429","authenticated-orcid":false,"given":"Wassim","family":"Saikali","sequence":"first","affiliation":[{"name":"Rheumatology and Pulmonary Clinic  Beckley West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-2781","authenticated-orcid":false,"given":"Suzanne","family":"Gharib","sequence":"additional","affiliation":[{"name":"The Rheumatology Group  South Charleston West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000163447.44037.c4"},{"key":"e_1_2_6_3_1","first-page":"1457","article-title":"Angiotensin\u2010converting enzyme2:SARS\u2010COV2 receotor and regulator of the rennin\u2010angiotensin system","volume":"125","author":"Gheblawi M","year":"2020","journal-title":"Circ Res"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.11335"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.448","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T19:52:58Z","timestamp":1693338778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":3,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/iid3.448"],"URL":"https:\/\/doi.org\/10.1002\/iid3.448","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"type":"print","value":"2050-4527"},{"type":"electronic","value":"2050-4527"}],"subject":[],"published":{"date-parts":[[2021,5,12]]},"assertion":[{"value":"2021-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}