{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:22Z","timestamp":1786977862597,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Although most patients recover within several weeks after acute COVID\u201019, some of them develop long\u2010lasting clinical symptoms. Renal transplant recipients have an increased mortality risk from COVID\u201019. We aimed to describe complications occurring after COVID\u201019 in this group of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective single\u2010center cohort study was conducted at University Hospital Centre Zagreb. Patients with two negative reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR) tests for SARS\u2010CoV\u20102 after COVID\u201019 were eligible for further follow\u2010up at our outpatient clinic. They underwent detailed clinical and laboratory assessments. The primary outcome was the development of complications after COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 11.53% of renal transplant recipients who survived acute COVID\u201019 were symptomless and free from new\u2010onset laboratory abnormalities during the median follow\u2010up of 64 days (range: 50\u201376 days). Three patients died from sepsis after discharge from the hospital. In 47 patients (45.2%), clinical complications were present, while 74 patients (71.2%) had one or more laboratory abnormalities. The most common clinical complications included shortness of breath (19.2%), tiredness (11.5%), peripheral neuropathy (7.7%), self\u2010reported cognitive impairments (5.7%), and dry cough (7.7%). Most common laboratory abnormalities included shortened activated partial thromboplastin time (50%), elevated D\u2010dimers (36.5%), elevated fibrinogen (30.16%), and hypogammaglobulinemia (24%). Positive RT\u2010PCR for cytomegalovirus (8.7%), Epstein\u2013Barr virus (26%), or BK virus (16.3%). Multivariate analysis identified the history of diabetes mellitus and eGFR CKD\u2010EPI as predictors for the development of post\u2010COVID clinical complications. Six months after acute COVID\u201019, elevated D\u2010dimers persisted with normalization of other laboratory parameters. Twenty\u2010nine patients were hospitalized, mostly with several concomitant problems. However, initially reported clinical problems gradually improved in the majority of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post\u2010COVID\u201019 clinical and laboratory complications are frequent in the renal transplant population, in some of them associated with significant morbidity. All patients recovered from acute COVID\u201019 should undergo long\u2010term monitoring for evaluation and treatment of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.509","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T03:42:19Z","timestamp":1629430939000},"page":"1563-1572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Follow\u2010up of renal transplant recipients after acute COVID\u201019\u2014A prospective cohort single\u2010center study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-2758","authenticated-orcid":false,"given":"Nikolina","family":"Basic\u2010Jukic","sequence":"first","affiliation":[{"name":"Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Clinical Hospital Centre Zagreb and School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Juric","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Clinical Hospital Centre Zagreb and School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Furic\u2010Cunko","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Clinical Hospital Centre Zagreb and School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Katalinic","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Clinical Hospital Centre Zagreb and School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josipa","family":"Radic","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Clinical Hospital Centre Split and Faculty of Medicine University of Split  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zrinka","family":"Bosnjak","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Microbiology  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Jelakovic","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Clinical Hospital Centre Zagreb and School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeljko","family":"Kastelan","sequence":"additional","affiliation":[{"name":"Department of Urology Clinical Hospital Centre Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6930e1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.08.029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32656-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12603"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202101-073LE"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00542-2020"},{"issue":"11","key":"e_1_2_7_9_1","first-page":"2120","article-title":"Delayed symptoms in patients recovered from COVID\u201019","volume":"49","author":"Moradian ST","year":"2020","journal-title":"Iran J Public Health"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.10.023"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15967"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15941"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa261"},{"issue":"4","key":"e_1_2_7_14_1","first-page":"145","article-title":"COVID\u201019 Mortality in Transplant Recipients","volume":"11","author":"Alfishawy M","year":"2020","journal-title":"Int J Organ Transplant Med"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa271"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr4200"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16185"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15929"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1097"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020050639"},{"key":"e_1_2_7_21_1","unstructured":"CoxDR&SnellEJ. 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