{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:21:53Z","timestamp":1782210113811,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000946","name":"Australian Lung Foundation","doi-asserted-by":"publisher","award":["Ludwig Engel Grant in aid for Physiological Research"],"award-info":[{"award-number":["Ludwig Engel Grant in aid for Physiological Research"]}],"id":[{"id":"10.13039\/501100000946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Normally functioning airway cilia is essential for efficient mucociliary clearance to protect the airway from various insults. Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation period is associated with airway infection, which we hypothesize may be caused by impaired cilia function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Airway cilia beating pattern (CBP) and frequency (CBF) were studied on brushing samples taken from above and below the transplant anastomosis of adult lung transplant recipients (<jats:italic>n<\/jats:italic>\u2009=\u200920) during routine bronchoscopies at 6, 12, and 26 weeks posttransplant. Bronchoaveolar Lavage (BAL) samples were also collected at each time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6 weeks posttransplant (<jats:italic>n<\/jats:italic>\u2009=\u200916), CBP from the donated lung showed reduced beating amplitude with the overall CBF 2.28\u2009Hz slower than the patients' native upper airway cilia (median\u2009\u00b1\u2009SIQR: 5.36\u2009\u00b1\u20090.93\u2009Hz vs. 7.64\u2009\u00b1\u20090.92\u2009Hz, <jats:italic>p<\/jats:italic> value\u2009&lt;\u2009.001). At 12 weeks (<jats:italic>n<\/jats:italic>\u2009=\u200916), donor lungs CBP showed recovery with the difference in CBF reduced to 0.74\u2009Hz (6.36\u2009\u00b1\u20091.46\u2009Hz vs. 7.10\u2009\u00b1\u20090.86\u2009Hz, <jats:italic>p<\/jats:italic> value\u2009&lt;\u2009.05). Impaired cilia function was not associated with positive BAL cultures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced cilia function is evident in the first 12 weeks post lung transplant, with both CBP and CBF returning to levels of function indistinguishable to the patients' upper airway cilia beyond this time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.527","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T13:50:08Z","timestamp":1632232208000},"page":"1716-1723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Airway cilia recovery post lung transplantation"],"prefix":"10.1002","volume":"9","author":[{"given":"Randy","family":"Suryadinata","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine,, Victorian Diagnostic Service for PCD The Royal Children's Hospital Melbourne Parkville Victoria Australia"},{"name":"Respiratory Diseases Murdoch Children's Research Institute Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kovi","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Lung Transplant Service The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Holsworth","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Lung Transplant Service The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Paraskeva","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Lung Transplant Service The Alfred Hospital Melbourne Victoria 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