{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:58:27Z","timestamp":1769824707104,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770046"],"award-info":[{"award-number":["81770046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970044"],"award-info":[{"award-number":["81970044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease (COVID\u201019) is a global infectious disease with a large burden of illness and high health care costs. This study aimed to compare clinical features among adult COVID\u201019 patients in different age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Laboratory\u2010confirmed adult COVID\u201019 infection cases between December 31, 2019 to March 8, 2020 obtained from Neighboring Cities. Patients were divided into five age groups. Clinical characteristics were compared among different age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 299 cases, median age was 44 and 158 (53%) were male. A total of 53.3% of 30\u201340 years, 50% of 40\u201350 years, 36.6% of &lt;30 years and 36.2% of 50\u201360 years were primary case, none of the elderly were primary case. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35% in patients with age &lt;30, 30\u201340, 40\u201350, 50\u201365, \u226565, respectively. A total of 285 patients (95.3%) were cured and discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.7%) deaths which occurred among persons \u226565\u2009years. Patients with a history of chronic heart disease had a more than a 56 times higher risk for severe or critical type of COVID\u201019 than those without a history of chronic heart disease (odds ratio [OR]: 56.038, 95% confidence interval [CI]: 2.764\u20131136.053, <jats:italic>p<\/jats:italic>\u2009=\u2009.009). Old age (OR: 1.055, 95% CI: 1.016\u20131.095, <jats:italic>p<\/jats:italic>\u2009=\u2009.006), high heart rate in admission (OR: 1.085, 95% CI: 1.03\u20131.144, <jats:italic>p<\/jats:italic>\u2009=\u2009.002), high respiratory rate in admission (OR: 1.635, 95% CI: 1.093\u20132.431, <jats:italic>p<\/jats:italic>\u2009=\u2009.017) were independently associated with severe or critical type in COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Proportion of severe or critical type increased with old age groups. Adults with old age and high heart rate, respiratory rate in admission and history of chronic heart disease were associated with severe or critical type in COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.550","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T08:57:15Z","timestamp":1635411435000},"page":"130-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparative clinical characteristics among different age group of adult COVID\u201019 patients: A multicenter study"],"prefix":"10.1002","volume":"10","author":[{"given":"Wei","family":"Cheng \u2020","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"Peng \u2020","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Affiliated Shaoyang Central Hospital of University of South China Shaoyang Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingding","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Attached Hospital of Shaoyang University Shaoyang Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Zhuzhou Central Hospital Zhuzhou Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Yueyang Second People's Hospital Designated Hospital of Junshan District Yueyang Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Medicine Xiangtan Central Hospital Xiangtan Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingcui","family":"Shuang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Attached Hospital of Shaoyang University Shaoyang Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-8636","authenticated-orcid":false,"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xucai","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Attached Hospital of Shaoyang University Shaoyang Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Covid19.who.int [homepage on the Internet]. WHO Coronavirus (COVID\u201019) Dashboard. Available from:https:\/\/covid19.who.int\/ accessed on July 172021."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25678"},{"key":"e_1_2_9_4_1","unstructured":"Voice.baidu.com [homepage on the Internet]. Real\u2010time big data report of the COVID\u201019's epidemic. Available from:https:\/\/voice.baidu.com\/act\/newpneumonia\/newpneumonia\/?from=osari_pc_3accessed on July 172021."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039908"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.30.2.269"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049936113518041"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265895"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061294"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1272-4"},{"key":"e_1_2_9_11_1","unstructured":"Chinese National Health Committee. The diagnostic and treatment guideline for novel coronavirus pneumonia(version seven). 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