{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:26Z","timestamp":1786977926469,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To reduce mortality in hospitalized patients with COVID\u201019 and cardiovascular disease (CVD), it is necessary to understand the relationship between patient's symptoms, risk factors, and comorbidities with their mortality rate. To the best of our knowledge, this paper is the first which take into account the determinants like risk factors, symptoms, and comorbidities leading to mortality in CVD patients who are hospitalized with COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was conducted on 660 hospitalized patients with CVD and COVID\u201019 recruited between January 2020 and January 2021 in Iran. All patients were diagnosed with the previous history of CVD like angina, myocardial infarction, heart failure, cardiomyopathy, abnormal heart rhythms, and congenital heart disease before they were hospitalized for COVID\u201019. We collected data on patient's signs and symptoms, clinical and paraclinical examinations, and any underlying comorbidities.\n                      <jats:italic>t<\/jats:italic>\n                      test was used to determine the significant difference between the two deceased and alive groups. In addition, the relation between pairs of symptoms and pairs of comorbidities has been determined via correlation computation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings suggest that signs and symptoms such as fever, cough, myalgia, chest pain, chills, abdominal pain, nausea, vomiting, diarrhea, and anorexia had no impact on patients' mortality. There was a significant correlation between COVID\u201019 cardiovascular patients' mortality rate and symptoms such as headache, loss of consciousness (LOC), oxygen saturation less than 93%, and need for mechanical ventilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results might help physicians identify early symptoms, comorbidities, and risk factors related to mortality in CVD patients hospitalized for COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.561","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T04:51:00Z","timestamp":1642654260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Factors associated with mortality in hospitalized cardiovascular disease patients infected with COVID\u201019"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-5054","authenticated-orcid":false,"given":"Roohallah","family":"Alizadehsani","sequence":"first","affiliation":[{"name":"Institute for Intelligent Systems Research and Innovation (IISRI) Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahimeh","family":"Eskandarian","sequence":"additional","affiliation":[{"name":"Internal Medicine Research Center Semnan University of Medical Sciences Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohaddeseh","family":"Behjati","sequence":"additional","affiliation":[{"name":"Rajaei Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Zahmatkesh","sequence":"additional","affiliation":[{"name":"Internal Medicine Research Center Semnan University of Medical Sciences Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Roshanzamir","sequence":"additional","affiliation":[{"name":"Department of Engineering Fasa University Fasa Fars Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid H.","family":"Izadi","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Isfahan University of Technology Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Shoeibi","sequence":"additional","affiliation":[{"name":"Computer Engineering Department Ferdowsi University of Mashhad Mashhad Iran"},{"name":"Faculty of Electrical and Computer Engineering, Biomedical Data Acquisition Lab K. N. Toosi University of Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Haddadi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculy of Basic Sciences, Shahrekord Branch Islamic Azad University Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahime","family":"Khozeimeh","sequence":"additional","affiliation":[{"name":"Institute for Intelligent Systems Research and Innovation (IISRI) Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba A.","family":"Sani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra A.","family":"Sani","sequence":"additional","affiliation":[{"name":"Department of Cardiac MRI Omid Hospital Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Roshanzamir","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Sleep Medicine Research Center, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Institute for Intelligent Systems Research and Innovation (IISRI) Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Nahavandi","sequence":"additional","affiliation":[{"name":"Institute for Intelligent Systems Research and Innovation (IISRI) Deakin University Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-2169","authenticated-orcid":false,"given":"Nizal","family":"Sarrafzadegan","sequence":"additional","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"},{"name":"Faculty of Medicine, SPPH University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7926-9368","authenticated-orcid":false,"given":"Sheikh Mohammed Shariful","family":"Islam","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences Deakin University Geelong Victoria Australia"},{"name":"Cardiovascular Division The George Institute for Global Health Newtown Australia"},{"name":"Sydney Medical School University of Sydney Camperdown Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Automated detection and forecasting of covid\u201019 using deep learning techniques: a review.","author":"Shoeibi A","year":"2020","journal-title":"arXiv"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2021.102622"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26699"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1145\/3462635"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00565-9"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Identification of clinical features associated with mortality in COVID\u201019 patients","author":"Eskandarian R","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"History of coronary heart disease increases the mortality rate of coronavirus disease 2019 (COVID\u201019) patients: a nested case\u2010control study based on publicly reported confirmed cases in Mainland China","author":"Gu T","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcaa246"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.054"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93543-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238215"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317062"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3319"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1017"},{"key":"e_1_2_8_16_1","first-page":"e102","article-title":"Retraction: cardiovascular disease, drug therapy, and mortality in Covid\u201019. 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