{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:26:31Z","timestamp":1772223991324,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) vaccines can cause adverse reactions, mainly from vaccine\u2010induced immune responses. Some of these may also involve the skin and worry unaware patients. A better understanding of such adverse reactions may reduce concerns and help promote the vaccination of large population groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the reports of patients admitted to our Dermatology Primary Care, from March 2021 to June 2021, were retrospectively examined to collect descriptive data on skin reactions arising after COVID\u201019 vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 200 vaccinated patients admitted to the Dermatology Primary Care, 21 (10.5%) referred cutaneous reactions with onset after vaccination. Only one patient required hospitalization for generalized bullous erythema multiforme, which occurred 48\u2009h after the second vaccine dose. The other patients' cutaneous reactions to vaccination were of mild\/moderate degree. Three patients presented exacerbation of their cutaneous diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cutaneous reactions observed in our sample were mostly mild or moderate. Awareness must be raised to recognize and treat eventual severe reactions. Future studies are needed to assess the incidence of cutaneous reactions following COVID\u201019 vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.568","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T08:46:24Z","timestamp":1638002784000},"page":"265-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cutaneous reactions to COVID\u201019 vaccine at the dermatology primary care"],"prefix":"10.1002","volume":"10","author":[{"given":"Martina","family":"Burlando","sequence":"first","affiliation":[{"name":"Department of Health Sciences (DISSAL), Section of Dermatology, San Martino Polyclinic Hospital IRCCS, Largo R University of Genova Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-8801","authenticated-orcid":false,"given":"Astrid","family":"Herzum","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), Section of Dermatology, San Martino Polyclinic Hospital IRCCS, Largo R University of Genova Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Micalizzi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), Section of Dermatology, San Martino Polyclinic Hospital IRCCS, Largo R University of Genova Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-4123","authenticated-orcid":false,"given":"Emanuele","family":"Cozzani","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), Section of Dermatology, San Martino Polyclinic Hospital IRCCS, Largo R University of Genova Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Parodi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), Section of Dermatology, San Martino Polyclinic Hospital IRCCS, Largo R University of Genova Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7002e1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7774\/cevr.2014.3.1.50"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7774\/cevr.2021.10.3.298"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5092"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2021.13.4.526"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9030221"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.12.047"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.092"},{"key":"e_1_2_9_10_1","unstructured":"Interim Clinical Considerations for Use of COVID\u201019Vaccines Currently Authorized in the United States. 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