{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:14:45Z","timestamp":1785838485437,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002567","name":"American Academy of Allergy Asthma and Immunology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asthma is a heterogenous disease that can be classified into eosinophilic (type 2\u2010high) and noneosinophilic (type 2\u2010low) endotypes. The type 2\u2010low endotype of asthma can be characterized by the presence of neutrophilic airway inflammation that is poorly responsive to corticosteroids. Dysregulated innate immune responses to microbial products including Toll\u2010like receptor (TLR) ligands have been associated with the pathogenesis of neutrophilic asthma. The key molecules that regulate inflammatory responses in individuals with neutrophilic asthma remain unclear. We previously reported that the immunoregulatory receptor neuropilin\u20102 (NRP2) is expressed by murine and human alveolar macrophage\u00a0(AM) and suppresses lipopolysaccharide (LPS)\u2010induced neutrophilic airway inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we investigated the immunoregulatory role of NRP2 in a mouse model of neutrophilic asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that TLR ligands, but not T helper 2 (Th2)\u2010promoting adjuvants, induced NRP2 expression by AM. Using an LPS\u2010mediated model of neutrophilic asthma, we demonstrate that NRP2 was increased in AM\u00a0and other lung antigen\u2010presenting cells following airway challenge with antigen. Conditional deletion of NRP2 in myeloid cells exacerbated airway inflammation in a neutrophilic asthma model. In contrast, myeloid\u2010specific ablation of NRP2 did not affect airway inflammation in a Th2\u2010mediated eosinophilic asthma model. Myeloid\u2010specific ablation of NRP2 did not affect Th1\/Th17 responses to inhaled antigens or expression of neutrophil chemokines but rather resulted in impaired efferocytosis by AM, which is necessary for effective resolution of airway inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that NRP2 is a negative regulator of airway inflammation associated with neutrophilic asthma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.575","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T20:13:36Z","timestamp":1638562416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neuropilin\u20102 regulates airway inflammation in a neutrophilic asthma model"],"prefix":"10.1002","volume":"10","author":[{"given":"Robert M.","family":"Immormino","sequence":"first","affiliation":[{"name":"Center for Environmental Medicine, Asthma and Lung Biology University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey M.","family":"Jania","sequence":"additional","affiliation":[{"name":"Department of Medicine University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Tilley","sequence":"additional","affiliation":[{"name":"Department of Medicine University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-9772","authenticated-orcid":false,"given":"Timothy P.","family":"Moran","sequence":"additional","affiliation":[{"name":"Center for Environmental Medicine, Asthma and Lung Biology University of North Carolina Chapel Hill North Carolina USA"},{"name":"Department of Pediatrics University of North Carolina Chapel Hill North Carolina 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