{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:11:19Z","timestamp":1790295079572,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Human Immunodeficiency virus (HIV) is a virus that causes several diseases by attacking the human immune system. It is transmitted by contact with certain bodily fluids of an infected person, most commonly during unprotected sex, through sharing needles, or from mother to baby during pregnancy, birth or breastfeeding. The central nervous system is not spared from this virus, as HIV has been shown to induce several neurological disorders. However most neurological pathologies (such as dementia, infections, meningitis, and neuropathy) rarely show until late stages, in this case, after the patients develop acquired immunodeficiency syndrome (AIDS). This article aims to review the neurological disorders in the HIV population and the attempts initiated to limit the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Data were collected from medical journals published on PubMed, Ovid MEDLINE, Science Direct and Embase bibliographical databases with a predefined search strategy. All articles considering neurological disorders associated with HIV were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To date, the pathogenesis of HIV\u2010associated neurological complications remains poorly elucidated; thus, imposing a hindrance and limitations on the treatment options. Nevertheless, some studies have reported alterations in dendritic spine as the causative agent for developing brain damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HIV remains one of the most serious global health challenges, with neurological manifestations imposing a major concern among patients with HIV. Despite the availability and efficacy of antiretroviral therapies, yet, the risk of developing neurological complications remains relatively high among patients with HIV. Thus, the 2030 HIV vision must focus on further preventive measures to protect HIV patients from developing such neurological complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.591","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T07:54:56Z","timestamp":1644566096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Neurological disorders in HIV: Hope despite challenges"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-9027","authenticated-orcid":false,"given":"Olivier","family":"Uwishema","sequence":"first","affiliation":[{"name":"Oli Health Magazine Organization, Research, and Education Kigali Rwanda"},{"name":"Clinton Global Initiative University New York New York USA"},{"name":"Faculty of Medicine Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-6779","authenticated-orcid":false,"given":"Georges","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Oli Health Magazine Organization, Research, and Education Kigali Rwanda"},{"name":"Faculty of Medicine Saint Joseph University of Beirut Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-4982","authenticated-orcid":false,"given":"Rawa","family":"Badri","sequence":"additional","affiliation":[{"name":"Oli Health Magazine Organization, Research, and Education Kigali Rwanda"},{"name":"Mycetoma Research Centre Khartoum Sudan"},{"name":"Faculty of Medicine University of Khartoum  Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3846-847X","authenticated-orcid":false,"given":"Helen","family":"Onyeaka","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-7217","authenticated-orcid":false,"given":"Christin","family":"Berjaoui","sequence":"additional","affiliation":[{"name":"Oli Health Magazine Organization, Research, and Education Kigali Rwanda"},{"name":"Faculty of Medicine and Surgery Beirut Arab University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-8477","authenticated-orcid":false,"given":"Ece","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Oli Health Magazine Organization, Research, and Education Kigali Rwanda"},{"name":"Faculty of Medicine Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4233-6445","authenticated-orcid":false,"given":"Heeba","family":"Anis","sequence":"additional","affiliation":[{"name":"Oli Health Magazine Organization, Research, and Education Kigali Rwanda"},{"name":"Deccan College of Medical Sciences Hyderabad Telangana India"},{"name":"Medtech Innovator Riga Technical University Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-289X","authenticated-orcid":false,"given":"Christophe","family":"Sammour","sequence":"additional","affiliation":[{"name":"Oli Health Magazine Organization, Research, and Education Kigali Rwanda"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Libre de Bruxelles Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1972-1401","authenticated-orcid":false,"given":"Fatima E. 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