{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:41:54Z","timestamp":1768322514320,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that causes inflammatory tissue damage, including lupus nephritis and vasculitis. Local generation of adhesion molecules and expression of their ligands on inflammatory cells appears to contribute to the progression of SLE. We found significantly increased E\u2010selectin expression in the glomeruli and renal interstitial microvasculature of MRL\/MpJ\u2010<jats:italic>lpr\/lpr<\/jats:italic> (MRL\/lpr) lupus model mice. This was accompanied with infiltration of inflammatory cells, especially macrophages and CD8<jats:sup>+<\/jats:sup> T cells. Similarly, in 21 patients with proliferative lupus nephritis, there was a significant correlation between renal E\u2010selectin levels and macrophage and CD8<jats:sup>+<\/jats:sup> T cell infiltration in the affected kidneys. By contrast, in transgenic MRL\/lpr mice exhibiting elevated levels of circulating soluble E\u2010selectin (sE\u2010selectin) protein, which competitively inhibits E\u2010 and P\u2010selectin\u2010mediated extravasation of inflammatory cells, the progression of lupus nephritis and vasculitis was significantly suppressed and survival was significantly prolonged. This improvement was accompanied by significant reductions in renal infiltration by macrophages and CD8<jats:sup>+<\/jats:sup> T cells. These results suggest that E\u2010selectin plays a crucial role in lupus nephritis and vasculitis by mediating renal infiltration of inflammatory cells, and that because it inhibits this process, sE\u2010selectin could potentially serve as an effective treatment for lupus nephritis and vasculitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.6","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:04:55Z","timestamp":1381529095000},"page":"37-46","source":"Crossref","is-referenced-by-count":10,"title":["Enhanced expression of the soluble form of E\u2010selectin attenuates progression of lupus nephritis and vasculitis in <scp>MRL<\/scp>\/lpr mice"],"prefix":"10.1002","volume":"1","author":[{"given":"Kimihiko","family":"Nakatani","sequence":"first","affiliation":[{"name":"Department of Pathology Nara Medical University Kashihara Nara Japan"},{"name":"First Department of Internal Medicine Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Asai","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Sakan","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Terada","sequence":"additional","affiliation":[{"name":"Division of Pathogenomics, Department of Pathology Ehime University Graduate School of Medicine To\u2010on Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Saito","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nose","sequence":"additional","affiliation":[{"name":"Division of Pathogenomics, Department of Pathology Ehime University Graduate School of Medicine To\u2010on Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Iwano","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Nara Medical University Kashihara Nara Japan"},{"name":"Division of Nephrology, Department of General Medicine Faculty of Medical Sciences, University of Fukui Yoshida\u2010gun Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Pathology Nara Medical University Kashihara Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"e_1_2_7_3_1","first-page":"S29","article-title":"Lupus nephritis: an historical perspective 1968\u20131998","volume":"12","author":"Cameron J. S.","year":"1999","journal-title":"J. Nephrol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00750.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-003-0124-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.004143"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.000553"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.181"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00537.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33488"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4189"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22654"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4307"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.2.581"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7185"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425672"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<2027::AID-IMMU2027>3.0.CO;2-S"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.04.012"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.2.147"},{"key":"e_1_2_7_21_1","first-page":"149","article-title":"Expression of intercellular adhesion molecule\u20101 and vascular adhesion molecule\u20101 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis","volume":"24","author":"Chen X.","year":"1995","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0061-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000190225"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0810477"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.367"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/6.12.917"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3912"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06107.x"},{"key":"e_1_2_7_29_1","first-page":"403","article-title":"Urinary soluble VCAM\u20101 in systemic lupus erythematosus: a clinical marker for monitoring disease activity and damage","volume":"20","author":"Molad Y.","year":"2002","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.7.1662"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920172"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9238"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2466335"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90267-O"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.4.8.791"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.4049\/jimmunol.151.6.3252","article-title":"L\u2010 and E\u2010selectin can recognize the same naturally occurring ligands on high endothelial venules","volume":"151","author":"Mebius R. E.","year":"1993","journal-title":"J. Immunol."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1105-1067"},{"key":"e_1_2_7_38_1","first-page":"173","article-title":"Lupus nephritis: update on pathogenesis and disease mechanisms","volume":"19","author":"Foster M. H.","year":"1999","journal-title":"Semin. Nephrol."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022694"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005091013"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011090914"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.73"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33488"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-008-0074-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22654"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2097::AID-ART360>3.0.CO;2-6"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/385081a0"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.3.573"},{"key":"e_1_2_7_49_1","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.4049\/jimmunol.162.6.3193","article-title":"Expression of functional selectin ligands on Th cells is differentially regulated by IL\u201012 and IL\u20104","volume":"162","author":"Lim Y. C.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_50_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.4049\/jimmunol.147.2.515","article-title":"IgG3 production in MRL\/lpr mice is responsible for development of lupus nephritis","volume":"147","author":"Takahashi S.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90076-0"},{"key":"e_1_2_7_52_1","first-page":"142","article-title":"Clinical usefulness of the morphological classification of lupus nephritis","volume":"2","author":"Baldwin D. S.","year":"1982","journal-title":"Am. J. Kidney Dis."},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330708"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-6-718"},{"key":"e_1_2_7_55_1","first-page":"255","article-title":"The role of renal biopsy in the management of lupus nephritis","volume":"5","author":"Schwartz M. M.","year":"1985","journal-title":"Semin. Nephrol."},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(87)80174-9"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiid3.6","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.6","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:09:04Z","timestamp":1696378144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/iid3.6"],"URL":"https:\/\/doi.org\/10.1002\/iid3.6","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}