{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:22:02Z","timestamp":1791595322840,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Myeloid\u2010derived suppressor cells (MDSCs) are a heterogeneous cell population with the ability to suppress immune responses.\u00a0MDSCs\u00a0usually cluster in cancer, inflammation, and autoimmune diseases. Although there have been some studies on MDSCs in non\u2010Hodgkin lymphoma (NHL), the correlation between the peripheral levels of MDSCs in patients with various subtypes of B cell NHL and clinical features and prognosis remains inconclusive.\u00a0This study aimed at the issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>101 patients with B cell NHL and 15 age\u2010matched healthy controls were included in this study. Flow cytometric detection of\u00a0monocytic\u2010MDSCs (M\u2010MDSCs)\u00a0and\u00a0granulocytic\u2010MDSCs (G\u2010MDSCs)\u00a0was done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, we found that counts of circulating M\u2010MDSCs\u00a0and\u00a0G\u2010MDSCs were significantly increased in different clinical statuses\u00a0of B\u2010NHL patients compared to healthy controls. Similarly, a significant increase in the levels of M\u2010MDSCs and G\u2010MDSCs was found among the diverse types of B\u2010NHL\u00a0compared\u00a0with healthy donors. Stratification studies indicated\u00a0MDSCs expansion was\u00a0closely associated with disease progression (tumor stage, LDH levels and B syndromes). Moreover, the overall survival time of\u00a0patients with G\u2010MDSCs (%) \u2265\u00a098.70%\u00a0was shorter than patients with G\u2010MDSCs (%)\u00a0&lt;\u00a098.70%\u00a0in\u00a0newly diagnosed\u00a0B\u2010NHL subgroup, meanwhile, there was a significant difference in survival of patients with M\u2010MDSCs\u00a0(%) \u2265\u00a07.19%\u00a0compared to patients with\u00a0M\u2010MDSCs\u00a0(%) &lt;\u00a07.19%\u00a0in relapsed B\u2010NHL subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggested that M\u2010MDSCs and G\u2010MDSCs may be a potential and efficient index to evaluate the prognosis of B\u2010NHL patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.616","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T18:24:13Z","timestamp":1650392653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Elevated circulating myeloid\u2010derived suppressor cells associated with poor prognosis in B\u2010cell non\u2010Hodgkin's lymphoma patients"],"prefix":"10.1002","volume":"10","author":[{"given":"Yangyang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Second Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Second Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology Second Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Second Hospital of Anhui Medical University Hefei Anhui 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