{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:46:28Z","timestamp":1769265988815,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2018\u2010I2M\u20102\u2010002"],"award-info":[{"award-number":["2018\u2010I2M\u20102\u2010002"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5U01AI151788\u201002"],"award-info":[{"award-number":["5U01AI151788\u201002"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000617","name":"Foreign and Commonwealth Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine the kinetics and persistence of immune responses following the Sinopharm\/BBIBP\u2010CorV, we investigated immune responses in a cohort of Sri Lankan individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SARS\u2010CoV\u20102 specific total antibodies were measured in 20\u201339 years (<jats:italic>n<\/jats:italic>\u2009=\u200961), 40\u201359 years (<jats:italic>n<\/jats:italic>\u2009=\u2009120) and those &gt;60 years of age (<jats:italic>n<\/jats:italic>\u2009=\u200922) by enzyme\u2010linked immunosorbent\u00a0assay, 12 weeks after the second dose of the vaccine. Angiotensin\u2010converting enzyme 2 (ACE2) receptor blocking antibodies (ACE2R\u2010Ab), antibodies to the receptor\u2010binding domain (RBD) of the ancestral virus (WT) and variants of concern, were measured in a sub cohort. T cell responses and memory B cell responses were assessed by ELISpot assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 193\/203 (95.07%) of individuals had detectable SARS\u2010CoV\u20102 specific total antibodies, while 67\/110 (60.9%) had ACE2R\u2010Ab. A total of 14.3%\u201316.7% individuals in the 20\u201339 age groups had detectable antibodies to the RBD of the WT and variants of concern, while the positivity rates of those \u226560 years of age was &lt;10%. A total of 14\/49 (28.6%) had Interferon gamma ELISpot responses to overlapping peptides of the spike protein, while memory B cell responses were detected in 9\/20 to the S1 recombinant protein. The total antibody levels and ACE2R\u2010Ab declined from 2 to 12 weeks from the second dose, while ex vivo T cell responses remained unchanged. The decline in ACE2R\u2010Ab levels was significant among the 40\u201359 (<jats:italic>p<\/jats:italic>\u2009=\u2009.0007) and \u226560 (<jats:italic>p<\/jats:italic>\u2009=\u2009.005) age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antibody responses declined in all age groups, especially in those \u226560 years, while T cell responses persisted. The effect of waning of immunity on hospitalization and severe disease should be assessed by long term efficacy studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.621","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:52:49Z","timestamp":1652255569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Persistence of immune responses to the Sinopharm\/BBIBP\u2010CorV vaccine"],"prefix":"10.1002","volume":"10","author":[{"given":"Chandima","family":"Jeewandara","sequence":"first","affiliation":[{"name":"Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine University of Sri Jayewardenepura Nugegoda Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inoka Sepali","family":"Aberathna","sequence":"additional","affiliation":[{"name":"Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine 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