{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:08Z","timestamp":1753869308943,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2019J01184","2021J05065"],"award-info":[{"award-number":["2019J01184","2021J05065"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We conducted a retrospective case\u2013control study to investigate the risk factors for osteonecrosis of the femoral head (ONFH) in rheumatoid arthritis (RA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of patients diagnosed with RA at Fujian Provincial Hospital from January 2013 to December 2020 were retrospectively collected and evaluated. Twenty\u2010two patients with ONFH were identified. Eighty\u2010eight age\u2010, sex\u2010, and disease duration\u2010matched RA patients without symptomatic ONFH were randomly selected as controls in a ratio of 1:4. Logistic regression analysis was used to analyze the risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anticardiolipin (ACL)\u2010immunoglobulin G (IgG) concentration, clinical disease activity index, simplified disease activity index, incidence of hyperlipidemia in the case group were higher than those in the control group. Multivariate logistic regression analysis did not find the independent risk factor in ONFH patients with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pathogenesis of ONFH in RA is related to many factors such as ACL IgG, disease activity index, and hyperlipidemia. While, we went to great lengths to explore the relationship between antiphospholipid antibodies and ONFH, but it plays a very small role.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.633","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:50:22Z","timestamp":1652255422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Symptomatic femoral head necrosis in patients with rheumatoid arthritis: A retrospective case\u2010control study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7791-0630","authenticated-orcid":false,"given":"Qijiao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Rheumatology Fujian Provincial Hospital  Fuzhou China"},{"name":"Fujian Medical University Provincial Clinical Medical College  Fuzhou 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Provincial Hospital  Fuzhou China"},{"name":"Fujian Medical University Provincial Clinical Medical College  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8030-8280","authenticated-orcid":false,"given":"He","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Fujian Provincial Hospital  Fuzhou China"},{"name":"Fujian Medical University Provincial Clinical Medical College  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-4553","authenticated-orcid":false,"given":"Zhihan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Fujian Provincial Hospital  Fuzhou China"},{"name":"Fujian Medical University Provincial Clinical Medical College  Fuzhou 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