{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:37:13Z","timestamp":1791466633285,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007414","name":"Qassim University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019\u00a0(COVID\u201019) infection is considered a serious highly infectious disease caused by severe acute respiratory syndrome coronavirus 2, resulting in more than 6.27 million deaths worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>The study aimed to compare clinical characteristics and laboratory findings of COVID\u201019 patients with complications and without complications and discriminate the important risk factors for the complications and deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This cross\u2010sectional study included 75 confirmed COVID\u201019 positive patients; out of which 49 were severely\u2010ill cases. Analysis of all patients' clinical and laboratory information on admission including serum ferritin, thrombotic activity (<jats:sc>d<\/jats:sc>\u2010dimer), lactate dehydrogenase (LDH), C\u2010reactive protein (CRP), creatinine, aspartate aminotransferase, and alanine aminotransferase\u00a0were done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lymphopenia, tachycardia, tachypnea, elevated CRP, <jats:sc>d<\/jats:sc>\u2010dimer, serum ferritin, LDH, and decreased SpO<jats:sub>2<\/jats:sub> were significantly associated with complicated cases (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 for all). By using multivariate logistic regression analysis models, elevated serum ferritin and tachycardia were significantly correlated with the increased odds of complicated COVID\u201019 cases (odds ratio [confidence interval 95%]\u2009=\u200910.42 [2.32\u201346.89] and 8.01 [1.17\u201355.99]; respectively) (<jats:italic>p<\/jats:italic>\u2009=\u2009.002 and\u00a0.007, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lymphocytopenia, <jats:sc>d<\/jats:sc>\u2010dimer, LDH, and CRP levels, which were significantly linked to the severity of COVID\u201019, were the prognostic biomarkers to predict the disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.671","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T11:11:06Z","timestamp":1657624266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison between clinical characteristics and laboratory findings among patients with complicated and noncomplicated SARS\u2010CoV\u20102 infection: A single\u2010center experience from Shebin Al\u2010Kom, Egypt"],"prefix":"10.1002","volume":"10","author":[{"given":"Walaa A.","family":"Fadda","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences Qassim University Unaizah Kingdom of Saudi Arabia"},{"name":"Department of Human Anatomy and Embryology, Menoufia Faculty of Medicine Menoufia University  Shebin Al\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-7470","authenticated-orcid":false,"given":"Manal A.","family":"Al\u2010Batanony","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Unaizah College of Medicine and Medical Sciences Qassim University  Unaizah Kingdom of Saudi Arabia"},{"name":"Department of Public Health and Community Medicine, Menoufia Faculty of Medicine Menoufia University  Shebin Al\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham E. 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