{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:11:16Z","timestamp":1792008676645,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The lungs are extremely vulnerable to ischemia\/reperfusion (I\/R), which is characterized by intense inflammation, oxidative stress, alveolar damage, and vascular permeability. Parecoxib sodium (Pare) has been shown to exert protective effects against multiple I\/R\u2010induced tissue injuries. However, its role in I\/R\u2010induced lung injury remains unknown. This study aimed to reveal the roles and mechanisms of Pare in pulmonary I\/R injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010six rats were randomly divided into three groups: The sham\u2010operated group, the pulmonary I\/R group, and the Pare\u2010pretreated I\/R group. Pare at 10\u2009mg\/kg or saline (vehicle control) were intraperitoneally administered to rats once per day for 5 consecutive days before ischemia. Serum and tissue samples were harvested following 2\u2009h of reperfusion. The oxygenation index (OI) and alveolar\u2010arterial oxygen partial pressure difference (PA\u2010aO<jats:sub>2<\/jats:sub>) were analyzed. The levels or activities of malondialdehyde, superoxidase dismutase, catalase, glutathione peroxidase, intracellular reactive oxygen species, tumor necrosis factor\u2010\u03b1, interleukin (IL)\u20106, and IL\u20108 were examined. The mitochondrial membrane potential\u00a0was measured. The protein expression levels of the extracellular signal\u2010regulated kinase (ERK), nuclear factor\u2010\u03baB (NF\u2010\u03baB) and their phosphorylated forms, and hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) were detected. Histological changes were observed using hematoxylin and eosin staining. Moreover, the survival rate following pulmonary I\/R injury was recorded daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pare significantly increased the OI, decreased the PA\u2010aO<jats:sub>2<\/jats:sub>, increased the levels of antioxidants, while decreasing the levels of oxidants, and alleviated mitochondrial dysfunction and the histopathological damage induced by I\/R. Furthermore, Pare inhibited the expression of proinflammatory cytokines, suppressed the activation of ERK and NF\u2010\u03baB, further increased HIF\u20101\u03b1 expression, and significantly improved the rat survival rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pare pretreatment attenuated lung I\/R injury by inhibiting oxidative stress and the inflammatory response possibly via inhibiting the activation of the ERK\/NF\u2010\u03baB pathway and further activating the HIF\u20101\u03b1 pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.684","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T12:08:18Z","timestamp":1660738098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Parecoxib sodium alleviates ischemia reperfusion\u2010induced pulmonary injury via inhibiting ERK\/NF\u2010\u03baB and further activating the HIF\u20101\u03b1 pathway"],"prefix":"10.1002","volume":"10","author":[{"given":"Jiantao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Taizhou First People's Hospital Huangyan Hospital Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-3639","authenticated-orcid":false,"given":"Yiping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taizhou First People's Hospital Huangyan Hospital Affiliated to Wenzhou Medical University Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228549"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158210"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000304"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.11.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c160006"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"1650","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu MY","year":"2018","journal-title":"Cell PhysiolBiochem"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6437467"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27411"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2019.109485"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00358-4"},{"issue":"13","key":"e_1_2_9_12_1","first-page":"2004","article-title":"Preconditioning of intravenous parecoxib attenuates focal cerebral ischemia\/reperfusion injury in rats","volume":"124","author":"Wang N","year":"2011","journal-title":"Chin Med J"},{"key":"e_1_2_9_13_1","first-page":"e928205","article-title":"Effect of parecoxib sodium on myocardial ischemia\u2010reperfusion injury rats","volume":"27","author":"Wu F","year":"2021","journal-title":"Med Sci Monit"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-015-0147-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020150040000006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12416"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.07.010"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.08.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.06.022"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3978"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8344-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.02.024"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7849"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159922"},{"issue":"5","key":"e_1_2_9_25_1","first-page":"613","article-title":"Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress\u2010induced gastric injury","volume":"65","author":"Kwiecien S","year":"2014","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3999"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.05.131"},{"issue":"3","key":"e_1_2_9_28_1","first-page":"233","article-title":"Role of antioxidants in the protection against oxidative stress in cattle\u2010\u2010trace elements and enzymatic mechanisms (part 3)","volume":"7","author":"Kleczkowski M","year":"2004","journal-title":"Pol J Vet Sci"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2018.05.019"},{"issue":"2","key":"e_1_2_9_30_1","first-page":"926","article-title":"Knockdown of TNF\u2010alpha alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL\u201010 expression","volume":"42","author":"Yang Z","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.12.005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6932"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/365654a0"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00353-3"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01038"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.11.006"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136923"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-23"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.08.029"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.08.078"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25074"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2011.76.010678"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21445"},{"issue":"1","key":"e_1_2_9_44_1","first-page":"370","article-title":"Dexmedetomidine alleviates lung ischemia\u2010reperfusion injury in rats by activating PI3K\/Akt pathway","volume":"23","author":"Liang S","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"8","key":"e_1_2_9_45_1","first-page":"14115","article-title":"Effect of preemptive analgesia with parecoxib sodium in patients undergoing radical resection of lung cancer","volume":"8","author":"Lu J","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.03.011"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000529"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108627"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1590\/acb360901"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.684","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T15:36:09Z","timestamp":1692459369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/iid3.684"],"URL":"https:\/\/doi.org\/10.1002\/iid3.684","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]},"assertion":[{"value":"2022-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e684"}}