{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:20:38Z","timestamp":1780489238664,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7234375"],"award-info":[{"award-number":["7234375"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Smoke inhalation lung injury (SILI) is a common complication in fires and wars, characterized by acute onset and severe condition. Pirfenidone (PFD), a new small\u2010molecule drug, has been shown to improve lung function and inhibit pulmonary fibrosis and inflammation. This study aimed to elucidate the effect and underlying mechanism of PFD on SILI in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>SILI rats were constructed using a homemade smoking device, which was then treated with PFD. The blood was collected from the abdominal aorta, and the arterial blood gas was detected. The productions of oxidative stress markers and inflammatory cytokines in plasma were measured by enzyme linked immunosorbent assay assay. Moreover, the alveolar surface area, wet:dry weight ratio of the lung tissues, and bronchoalveolar lavage fluid (BALF) were determined as well. The pulmonary histopathology, cell apoptosis, and the related proteins of nuclear factor kappa B (NF\u2010\u03baB) pathway were determined by hematoxylin\u2010eosin staining, TdT\u2010mediated dUTP\u2010biotin nick end labeling, and western blot assays, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PFD had a significant protective effect on SILI via inhibiting oxidative stress, inflammation, and apoptosis. Mechanistically, PFD inhibited the activation of NF\u2010\u03baB pathway in vivo. Moreover, activation of NF\u2010\u03baB pathway attenuated the PFD\u2010mediated protective effect against SILI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data demonstrate that PFD alleviates SILI of rats via the NF\u2010\u03baB signaling pathway, which provides an attractive therapeutic option for SILI treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70014","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T07:39:01Z","timestamp":1732606741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pirfenidone alleviates smoke inhalation lung injury of rats via the NF\u2010\u03baB signaling pathway"],"prefix":"10.1002","volume":"12","author":[{"given":"Tingting","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8298-3424","authenticated-orcid":false,"given":"Jinxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.10.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111586"},{"key":"e_1_2_11_4_1","first-page":"4712","article-title":"Edaravone attenuates smoke inhalation injury in rats by the Notch pathway","volume":"13","author":"Xiao C","year":"2021","journal-title":"Am J Transl Res"},{"key":"e_1_2_11_5_1","first-page":"2563","article-title":"Aerosol inhalation of edaravone can improve inflammation, oxidative stress and pulmonary function of rats with smoke inhalation injury by down\u2010regulating miR\u2010320","volume":"13","author":"Xiao C","year":"2021","journal-title":"Am J Transl Res"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92471-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000059312.90697.32"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13112118"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2022-219795"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118454"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104694"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.631891"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.907891"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00706-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37438-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121048"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.12.034"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102464"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.09.023"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12651"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16050697"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118042"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114066"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1937905"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118042"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2023.02.008"},{"key":"e_1_2_11_27_1","unstructured":"ShubertJ SharmaS Inhalation Injury StatPearls Treasure Island (FL) ineligible companies. Disclosure: Sandeep Sharma declares no relevant financial relationships with ineligible companies. 2023."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233425"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22693"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2012.02.019"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185937"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9111064"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.05.003"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.078030"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12565"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-020-02364-5"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115833"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014861"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.01.014"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T07:14:44Z","timestamp":1763709284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/iid3.70014"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70014","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70014"}}