{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:49:22Z","timestamp":1776156562956,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to enhance the management of Epstein\u2010Barr Virus (EBV) infections by analyzing the correlation between laboratory indicators and clinical manifestations in children, thereby proposing more precise diagnostic and treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study included 163 pediatric patients with EBV infections treated at the Children's Hospital of Soochow University from December 2017 to December 2019. Data collected through retrospective analysis included gender, age, clinical symptoms, signs, liver function tests, T\u2010cell subset distribution, EBV\u2010DNA copy numbers in plasma, and treatment outcomes. Patients were grouped based on EBV\u2010DNA copy numbers in plasma and hospital stay duration to compare clinical indicators across different groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dichotomous results of EBV\u2010DNA copy numbers in plasma showed that the two groups of children were significantly different in the number of days of fever (<jats:italic>p<\/jats:italic>\u2009=\u2009.0022), platelet count (<jats:italic>p<\/jats:italic>\u2009=\u2009.0212), ALT (<jats:italic>p<\/jats:italic>\u2009=\u2009.001), immunoglobulin IgM (<jats:italic>p<\/jats:italic>\u2009=\u2009.0039), IgG (<jats:italic>p<\/jats:italic>\u2009=\u2009.0195), TBiL (<jats:italic>p<\/jats:italic>\u2009=\u2009.025), LDH (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001), and length of hospital stay (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were significantly different, indicating that EBV\u2010DNA copy numbers in plasma may be correlated with these characteristic variables. The dichotomous results of the length of hospital stay showed that the two groups were significantly increased in tonsil enlargement (<jats:italic>p<\/jats:italic>\u2009=\u2009.0024), platelet count (<jats:italic>p<\/jats:italic>\u2009=\u2009.0059), LDH (<jats:italic>p<\/jats:italic>\u2009=\u2009.0394), and ferritin (<jats:italic>p<\/jats:italic>\u2009=\u2009.0106) and EBV\u2010DNA copy numbers in plasma (<jats:italic>p<\/jats:italic>\u2009=\u20090.0361) were significantly different, This suggests a potential correlation between EBV\u2010DNA copy numbers in plasma and these clinical indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variations in platelet counts and lactate dehydrogenase (LDH) levels in children with EBV infections may serve as indicators of clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70020","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:39:02Z","timestamp":1726472342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical analysis of 163 pediatric patients with infectious mononucleosis: a single\u2010center retrospective analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-308X","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Children's Hospital Zhejiang University School of Medicine  National Clinical Research Center for Child Health.3333 Binsheng Road, Binjiang District Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7667-2873","authenticated-orcid":false,"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Children's Hospital of Soochow University No.92 Zhongnan Street Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1093719"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1064330"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064921"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit096"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2019.03.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.809005"},{"key":"e_1_2_11_8_1","first-page":"609","article-title":"Epidemiology of Epstein\u2010Barr virus (EBV) infection and EBV\u2010associated diseases","volume":"64","author":"Maeda A","year":"2006","journal-title":"Nihon rinsho. 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