{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:36:21Z","timestamp":1785278181169,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diarrhea is a leading cause of death in young children worldwide. Vitamin D deficiency impairs the body's ability to clear pathogens, reduces tight junction protein expression in intestinal epithelial cells, and enhances Th1\u2010mediated intestinal inflammation. This study aimed to investigate the effects of serum vitamin D levels on acute invasive enteritis in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study included 82 children aged 1\u20133 years with clinically diagnosed acute invasive enteritis at Sichuan Maternal and Child Health Hospital from February 2021 to February 2022, alongside a control group of 80 healthy children. Fecal specimens were collected for routine tests and occult blood analysis, while blood samples were taken for routine tests, C\u2010reactive protein, and 25\u2010OHD levels. Comparative analyses were performed between groups, and multifactorial logistic regression was used to identify factors influencing invasive enteritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group showed significantly lower serum 25\u2010OHD levels (27.95\u2009\u00b1\u20099.91\u2009ng\/mL) compared to controls (32.76\u2009\u00b1\u200910.23\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Among the study group, 19.5% (16\/82) had levels &lt;20\u2009ng\/mL, versus 12.5% (10\/80) in controls. Regular vitamin D supplementation was lower in the study group (58.5% vs. 77.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Outdoor activity duration was also reduced (2.57\u2009\u00b1\u20090.98\u2009h vs. 3.04\u2009\u00b1\u20090.88\u2009h, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Multivariate analysis identified that exclusive breastfeeding, greater outdoor activity time and regular vitamin D supplementation were all associated with reduced risk of invasive enteritis (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings indicate an association between low serum 25\u2010OHD levels and acute invasive enteritis in children aged 1\u20103 years, suggesting that consistent vitamin D supplementation and sufficient outdoor activity may protect against this condition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70024","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:25:14Z","timestamp":1727184314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation between serum vitamin D level and acute invasive enteritis in children"],"prefix":"10.1002","volume":"12","author":[{"given":"Lingrong","family":"Yang","sequence":"first","affiliation":[{"name":"Sichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fang","sequence":"additional","affiliation":[{"name":"The Second School of Medicine Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Second School of Medicine Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1693-1228","authenticated-orcid":false,"given":"Fu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31593-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30401-3"},{"key":"e_1_2_12_4_1","unstructured":"World Health O. The treatment of diarrhoea: a manual for physicians and other senior health workers.2005."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14020216"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887115666200628144128"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001107"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2018.61.3.84"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-018-0190-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-020-0713-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32225-6"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186573"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09532-w"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2017.02.001"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0526-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-021-09679-5"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i17.5191"},{"issue":"7","key":"e_1_2_12_18_1","article-title":"Vitamin D supplementation for women during pregnancy","volume":"7","author":"Palacios C","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_19_1","first-page":"387","article-title":"[Practical guidelines for clinical issues related to vitamin D nutrition in Chinese children]","volume":"60","author":"Subspecialty Group of Children Health, t.S.o.P.C.M.A.; Editorial Board, C.J.o.P","year":"2022","journal-title":"Zhonghua er ke za zhi"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2011.01.019"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-016-0157-2"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92132-z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01678-x"},{"key":"e_1_2_12_24_1","first-page":"791","article-title":"[Relationship between vitamin D deficiency and early\u2010onset neonatal sepsis]","volume":"18","author":"Yang LR","year":"2016","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168872"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2019.1611734"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071129"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12809"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0523"},{"key":"e_1_2_12_30_1","first-page":"178","article-title":"[Relationship between vitamin D deficiency and necrotizing enterocolitis in preterm infants]","volume":"20","author":"Yang LR","year":"2018","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2017-0391"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.120873"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000778"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.604080"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz037"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T18:03:54Z","timestamp":1744394634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/iid3.70024"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70024","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70024"}}