{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:04:14Z","timestamp":1785855854972,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The relationship between systemic immune\u2010inflammation index (SII) and psoriasis and its prognosis is not yet clear. In this study, the correlation between SII and psoriasis, psoriasis comorbidities, and all\u2010cause mortality was investigated based on the National Health and Nutrition Examination Survey (NHANES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population was derived from five NHANES cycles: 2003\u20132006, 2009\u20132014, and survival follow\u2010up was as of December 31, 2019. The association between SII and psoriasis and its comorbidities was analyzed using weighted multivariate logistic regression models. Weighted COX regression was used to calculate hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs). Restricted cubic spline, subgroup and sensitivity analyses were also used. Logarithmic conversion was performed on SII(log2SII) to reduce the impact of outliers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 21,431 participants were included in this study. As a continuous variable, log2SII was significantly associated with psoriasis in the fully adjusted model [OR\u2009=\u20091.20(1.04\u20131.39), <jats:italic>p<\/jats:italic>\u2009=\u2009.01]. log2SII remained positively associated with psoriasis after excluding participants with a history of cancer or cardiovascular disease (CVD), or non\u2010Hispanic black participants. Among psoriasis patients, log2SII was significantly associated with metabolic syndrome (MetS) [OR\u2009=\u20091.68(1.19,2.38), <jats:italic>p<\/jats:italic>\u2009=\u2009.004] and all\u2010cause mortality [HR\u2009=\u20091.48(1.09,1.99), <jats:italic>p<\/jats:italic>\u2009=\u2009.01]. Similar results were consistently observed when SII was analyzed as a categorical variable (in quartiles).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggested a positive association between SII and the prevalence of psoriasis. Among psoriasis patients, SII was positively correlated with MetS and all\u2010cause mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.70050","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:54:35Z","timestamp":1730141675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association Between Systemic Immune\u2010Inflammation Index and Psoriasis, Psoriasis Comorbidities, and All\u2010Cause Mortality: A Study Based on NHANES"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7781-3941","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Ping","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-6464","authenticated-orcid":false,"given":"Lin Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-016-8535-x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13806"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S439110"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000300"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.07.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-92616-8_4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2022.22.e7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076111"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-015-1489-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22964"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519860686"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2019.87498"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i34.6261"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-020-01974-w"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00785-x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.922595"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03924-y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/6988489","article-title":"Prognostic and Clinical Value of the Systemic Immune\u2010Inflammation Index in Biliary Tract Cancer: A Meta\u2010Analysis","volume":"2022","author":"Peng X.","year":"2022","journal-title":"Journal of Immunology Research"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.537140"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.08.116"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.25691"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01308-6"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14101"},{"issue":"4","key":"e_1_2_11_25_1","first-page":"352","article-title":"Systemic Immune\u2010Inflammation Index (SII) Predicts Increased Severity in Psoriasis and Psoriatic Arthritis","volume":"46","author":"Yorulmaz A.","year":"2020","journal-title":"Current health sciences journal"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.026"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1803"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01970309"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-02115-9"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.2007"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1099"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00507-9"},{"issue":"21","key":"e_1_2_11_34_1","first-page":"2095","article-title":"Psoriatic Arthritis","volume":"376","author":"Ritchlin C. 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